A comparison of microstructural maturational changes of the corpus callosum in preterm and full-term children: a diffusion tensor imaging study

Title
A comparison of microstructural maturational changes of the corpus callosum in preterm and full-term children: a diffusion tensor imaging study
Author(s)
손수민장성호이은실조해민조희경여상석김한선
Keywords
WHITE-MATTER CHANGES; EQUIVALENT AGE; SEX-DIFFERENCES; CEREBRAL-PALSY; YOUNG-ADULTS; INFANTS; BRAIN; BIRTH; ABNORMALITIES; ADOLESCENTS
Issue Date
201209
Publisher
SPRINGER
Citation
NEURORADIOLOGY, v.54, no.9, pp.997 - 1005
Abstract
Preterm children with thinning of the corpus callosum (CC) frequently achieve poor neurodevelopmental outcomes despite the absence of a definite brain lesion. Here, the authors compared the microstructural characteristics of the CC in preterm and full-term children using diffusion tensor imaging (DTI). Twenty-two preterm children with no definite focal lesion but with thinning of the CC by conventional magnetic resonance imaging and 23 age-matched full-term children were investigated by DTI. CCs were subdivided into genu, rostral body, body, isthmus, and splenium, and voxel counts (VC), fractional anisotropies (FA), and apparent diffusion coefficients (ADC) were measured in each subdivision. Eleven preterm and 11 age-matched full-term subjects underwent follow-up scanning and interval changes in these parameters for each subdivision were compared. VC and FA were significantly lower in the preterm group than in the full-term group, particularly in the isthmus. Furthermore, incremental changes in VC and FA were significantly smaller in the preterm group. Differences in maturation between the two groups were more pronounced with age in all subdivisions except the splenium. At all ages, noticeable FA differences between the two groups were observed in the isthmus. For white matter tracts, the preterm group displayed lower FA and fiber number, higher ADC values than the term group. The present study shows that thinning of the CC is correlated with lower FA value and that it is more pronounced in preterm children. In addition, the isthmus was found to be the most vulnerable subdivision in preterm children.
URI
http://hdl.handle.net/YU.REPOSITORY/27345http://dx.doi.org/10.1007/s00234-012-1042-8
ISSN
0028-3940
Appears in Collections:
의과대학 > 재활의학교실 > Articles
의과대학 > 소아청소년과학교실 > Articles
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