Homodimeric SV40 NLS peptide formed by disulfide bond as enhancer for gene delivery

Title
Homodimeric SV40 NLS peptide formed by disulfide bond as enhancer for gene delivery
Author(s)
이태진김병길[김병길]강현구[강현구]도경오이성혜박종원이수진[이수진]
Keywords
HIV-1 TAT PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS; CATIONIC LIPOSOMES; DNA; TRANSFECTION; CARRIERS; COMPLEXES; THERAPY; CANCER; POTENT
Issue Date
201209
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.22, no.17, pp.5415 - 5418
Abstract
Recently, cysteine residue incorporation increased liposome-mediated transfection compared to unmodified peptide. Therefore, we designed novel modified SV40 NLS peptides, homodimeric (NLS-CTHD, NLS-NTHD) and closed structure (cyclic NLS), simply using disulfide bond between cysteines to develop more efficient and safe non-viral gene delivery system. The simple mix of NLS-CTHD among these novel transfection enhancing peptides with DNA increased the gene transfer potency of cationic liposomes more efficiently with no additional cytotoxicity. (C) 2012 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/27342http://dx.doi.org/10.1016/j.bmcl.2012.07.051
ISSN
0960-894X
Appears in Collections:
의과대학 > 해부학교실 > Articles
의과대학 > 생리학교실 > Articles
의과대학 > 내과학교실 > Articles
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