Usefulness of Glycated Hemoglobin as Diagnostic Criteria for Metabolic Syndrome

Title
Usefulness of Glycated Hemoglobin as Diagnostic Criteria for Metabolic Syndrome
Author(s)
윤지성박상현[ 박상현]원규장이형우
Keywords
FASTING PLASMA-GLUCOSE; CARDIOVASCULAR-DISEASE; GLYCOSYLATED HEMOGLOBIN; INSULIN-RESISTANCE; DIABETES-MELLITUS; RISK-FACTORS; HBA(1C); POPULATION; PREDICTOR; ADULTS
Issue Date
201209
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.27, no.9, pp.1057 - 1061
Abstract
The metabolic syndrome (MetS) is the clustering of cardiovascular risk factors and known as a powerful predictor of diabetes and cardiovascular disease. Glycated hemoglobin (HbA1c) is used as one of the diagnostic criteria for diabetes and category of increased risk for diabetes. We examined the usefulness of HbA1c as a diagnostic tool for MetS and to determine the cut-off value of HbA1c as a criterion for MetS, in non-diabetic Korean subjects. We analyzed 7,307 participants (male: 4,181, 57%) in a medical check-up program, and applied the newly recommended guidelines of the International Diabetes Federation for diagnosis of MetS. The mean HbA1c was 5.54% in all subjects and showed no significant difference between genders. Using receiver-operating characteristic curve, HbA1c value corresponding to the fasting plasma glucose value of 100 mg/dL was 5.65% (sensitivity 52.3%, specificity 76.7%). The prevalence of MetS was 8.5% according to the IDF guideline and 10.9% according to HbA1c value of 5.7%, showing 69.5% agreement rate. The detection rate of MetS increased to 25.7% using the HbA1c criterion of 5.7% instead of fasting hyperglycemia. This study suggests that HbA1c might be used as a diagnostic criterion for MetS and the appropriate cut-off value of HbA1c may be 5.65% in this Korean population.
URI
http://hdl.handle.net/YU.REPOSITORY/27337http://dx.doi.org/10.3346/jkms.2012.27.9.1057
ISSN
1011-8934
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의과대학 > 내과학교실 > Articles
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