Depot-specific gene expression profiles during differentiation and transdifferentiation of bovine muscle satellite cells, and differentiation of preadipocytes

Title
Depot-specific gene expression profiles during differentiation and transdifferentiation of bovine muscle satellite cells, and differentiation of preadipocytes
Author(s)
최인호이은주이현정[이현정]마지드라술캄리포커렐스미리티압둘루프바트이용호[이용호]최봉환[최봉환]전태훈[전태훈]강세원[강세원]이용석[이용석]김재우[김재우]Robert D. Schnabel[Robert D. Schnabel]Jeremy F.Taylor[Jeremy F.Taylor]
Keywords
ADIPOSE-LIKE CELLS; STEM-CELLS; ADIPOGENIC DIFFERENTIATION; ADIPOCYTE DIFFERENTIATION; SKELETAL-MUSCLE; FATTY-ACIDS; PPAR-GAMMA; TISSUE; PATTERNS; PROTEIN
Issue Date
201209
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
GENOMICS, v.100, no.3, pp.195 - 202
Abstract
We report a systematic study of gene expression during myogenesis and transdifferentiation in four bovine muscle tissues and of adipogenesis in three bovine fat tissues using DNA microarray analysis. One hundred hybridizations were performed and 7245 genes of known and unknown function were identified as being differentially expressed. Supervised hierarchical cluster analysis of gene expression patterns revealed the tissue specificity of genes. A close relationship in global gene expression observed for adipocyte-like cells derived from muscle and adipocytes derived from intramuscular fat suggests a common origin for these cells. The role of transthyretin in myogenesis is a novel finding. Different genes were highly induced during the transdifferentiation of myogenic satellite cells and in the adipogenesis of preadipocytes, indicating the involvement of different molecular mechanisms in these processes. Induction of CD36 and FABP4 expression in adipocyte-like cells and adipocytes may share a common pathway. (C) 2012 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/27323http://dx.doi.org/10.1016/j.ygeno.2012.06.005
ISSN
0888-7543
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