alpha-Iso-cubebene, a natural compound isolated from Schisandra chinensis fruit, has therapeutic benefit against polymicrobial sepsis

Title
alpha-Iso-cubebene, a natural compound isolated from Schisandra chinensis fruit, has therapeutic benefit against polymicrobial sepsis
Author(s)
백석환Sung Kyun Lee[Sung Kyun Lee]Sang Doo Kim[Sang Doo Kim]Ha Young Lee[Ha Young Lee]Min Jung Ko[Min Jung Ko]Beung Gu Son[Beung Gu Son]Sejin Park[Sejin Park]Young Whan Choi[Young Whan Choi]Yoe-sik Bae[Yoe-sik Bae]
Keywords
INTERLEUKIN-1 RECEPTOR ANTAGONIST; INDUCED APOPTOSIS; CYTOKINE PROFILE; DOUBLE-BLIND; TRIAL; PRO
Issue Date
201209
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.426, no.2, pp.226 - 231
Abstract
alpha-Iso-cubebene, a natural compound isolated from Schisandra chinensis fruit, strongly enhanced survival rate in cecal ligation and puncture (CLP) challenge-induced sepsis. The mechanism involved the marked reduction of viable bacteria in the peritoneal fluid, by virtue of increased phagocytic activity and production of hydrogen peroxide. alpha-Iso-cubebene also significantly attenuated lung inflammation and widespread immune cell apoptosis in a mouse CLP sepsis model, and inhibited the production of proinflammatory cytokines including tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL-6 in CLP mice and lipopolysaccharide-stimulated splenocytes. The results indicate that alpha-iso-cubebene can reverse the progression of toxic shock by triggering multiple protective downstream signaling pathways to enhance microbial killing and maintain organ function and leukocyte survival. (C) 2012 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/27318http://dx.doi.org/10.1016/j.bbrc.2012.08.070
ISSN
0006-291X
Appears in Collections:
의과대학 > 생화학.분자생물학교실 > Articles
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