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dc.contributor.author최혁재ko
dc.contributor.authorWeihong Wang[Weihong Wang]ko
dc.contributor.authorYeehee Lee[Yeehee Lee]ko
dc.contributor.authorTae Gu Lee[Tae Gu Lee]ko
dc.contributor.authorBora Mun[Bora Mun]ko
dc.contributor.authorAwadut G. Giri[Awadut G. Giri]ko
dc.contributor.authorJihye Lee[Jihye Lee]ko
dc.contributor.authorHiyoung Kim[Hiyoung Kim]ko
dc.contributor.authorDongyup Hahn[Dongyup Hahn]ko
dc.contributor.authorInho Yang[Inho Yang]ko
dc.contributor.authorJungwook Chin[Jungwook Chin]ko
dc.contributor.authorSang-Jip Nam[Sang-Jip Nam]ko
dc.contributor.authorHeonjoong Kang[Heonjoong Kang]ko
dc.date.accessioned2015-12-17T02:12:25Z-
dc.date.available2015-12-17T02:12:25Z-
dc.date.created2015-11-13-
dc.date.issued201209-
dc.identifier.citationORGANIC LETTERS, v.14, no.17, pp.4486 - 4489-
dc.identifier.issn1523-7060-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/27299-
dc.identifier.urihttp://dx.doi.org/10.1021/ol3019874-
dc.description.abstractA chemical investigation of a Korean marine sponge, Phorbas sp., yielded unprecedented sesterterpenoids phorone A (1) and isophorbasone A (2) along with ansellone B (3) and phorbasone A acetate (4). Their complete structures were elucidated by the combination of spectroscopic data and chemical manipulation. Phorone A (1) and isophorbasone A (2) have the new "phorane" (5) and "isophorbasane' (6) sesterterpenoid carbon skeletons, respectively. Ansellone B (3) and phorbasone A acetate (4) exhibited potent inhibitory activity on nitric oxide production in RAW 264.7 LPS-activated mouse macrophage cells with IC50 values of 4.5 and 2.8 mu M, respectively.-
dc.language영어-
dc.publisherAMER CHEMICAL SOC-
dc.subjectSTRUCTURE ELUCIDATION-
dc.subjectA-D-
dc.subjectG-I-
dc.subjectDITERPENES-
dc.subjectAMARANTHUS-
dc.subjectCONFIGURATIONS-
dc.subjectPHORBOXAZOLE-
dc.subjectGUKULENSIS-
dc.subjectMACROLIDES-
dc.subjectCD-
dc.titlePhorone A and Isophorbasone A, Sesterterpenoids Isolated from the Marine Sponge Phorbas sp.-
dc.typeArticle-
dc.identifier.wosid000308390000048-
dc.identifier.scopusid2-s2.0-84866042792-
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