Phorone A and Isophorbasone A, Sesterterpenoids Isolated from the Marine Sponge Phorbas sp.

Title
Phorone A and Isophorbasone A, Sesterterpenoids Isolated from the Marine Sponge Phorbas sp.
Author(s)
최혁재Weihong Wang[Weihong Wang]Yeehee Lee[Yeehee Lee]Tae Gu Lee[Tae Gu Lee]Bora Mun[Bora Mun]Awadut G. Giri[Awadut G. Giri]Jihye Lee[Jihye Lee]Hiyoung Kim[Hiyoung Kim]Dongyup Hahn[Dongyup Hahn]Inho Yang[Inho Yang]Jungwook Chin[Jungwook Chin]Sang-Jip Nam[Sang-Jip Nam]Heonjoong Kang[Heonjoong Kang]
Keywords
STRUCTURE ELUCIDATION; A-D; G-I; DITERPENES; AMARANTHUS; CONFIGURATIONS; PHORBOXAZOLE; GUKULENSIS; MACROLIDES; CD
Issue Date
201209
Publisher
AMER CHEMICAL SOC
Citation
ORGANIC LETTERS, v.14, no.17, pp.4486 - 4489
Abstract
A chemical investigation of a Korean marine sponge, Phorbas sp., yielded unprecedented sesterterpenoids phorone A (1) and isophorbasone A (2) along with ansellone B (3) and phorbasone A acetate (4). Their complete structures were elucidated by the combination of spectroscopic data and chemical manipulation. Phorone A (1) and isophorbasone A (2) have the new "phorane" (5) and "isophorbasane' (6) sesterterpenoid carbon skeletons, respectively. Ansellone B (3) and phorbasone A acetate (4) exhibited potent inhibitory activity on nitric oxide production in RAW 264.7 LPS-activated mouse macrophage cells with IC50 values of 4.5 and 2.8 mu M, respectively.
URI
http://hdl.handle.net/YU.REPOSITORY/27299http://dx.doi.org/10.1021/ol3019874
ISSN
1523-7060
Appears in Collections:
약학대학 > 약학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE