Serum concentrations of major perfluorinated compounds among the general population in Korea: Dietary sources and potential impact on thyroid hormones

Title
Serum concentrations of major perfluorinated compounds among the general population in Korea: Dietary sources and potential impact on thyroid hormones
Author(s)
사공준지경희[지경희]김선미[김선미]고영림[고영림]백도명[백도명]하종식[하종식]김성균[김성균]최경호[최경호]
Keywords
PERFLUOROOCTANE SULFONATE; HUMAN BLOOD; CYNOMOLGUS MONKEYS; NHANES 1999-2000; NATIONAL-HEALTH; DRINKING-WATER; US POPULATION; CHEMICALS; ACIDS; FLUOROCHEMICALS
Issue Date
201209
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
ENVIRONMENT INTERNATIONAL, v.45, pp.78 - 85
Abstract
Perfluorinated compounds (PFCs) have been frequently detected in both the environment and biota, and have become a growing concern. However, information is limited on the potential sources and human health implications of such exposure. We evaluated the exposure levels of 13 major PFCs among a population (n = 633, > 12 years of age) in a mid-sized city of Korea, and investigated for their potential dietary sources and the impact on thyroid hormone concentrations. For this purpose, we collected blood samples from a general population in Siheung, Korea and measured for 13 PFCs, total thyroxine (T4), and thyroid stimulating hormone (TSH). In addition, a questionnaire survey on diet was conducted. Perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA) were detected in relatively greater concentrations than the other 9 PFCs in the blood serum. Males tend to have greater concentrations than females for most PFCs, and the concentrations were elevated as age increased up to 50s. Body mass index (BMI) was also shown to influence the serum concentrations of several PFCs. After adjustment for age, sex, and BMI, the consumption of vegetable, potato, fish/shellfish, and popcorn was identified to be significantly related with concentrations of major PFCs in blood. Among the studied PFCs, the concentrations of perfluorotridecanoic acid (PFTrDA) were negatively correlated with total T4, and positively with TSH levels, especially among females. The result of this study will provide information useful for developing public health and safety management measures for PFCs. (c) 2012 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/27272http://dx.doi.org/10.1016/j.envint.2012.03.007
ISSN
0160-4120
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의과대학 > 예방의학교실 > Articles
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