Extracts of oyster mushroom (Pleurotus ostreatus) grown on wheat ameliorate hepatotoxicity induced by carbon tetrachloride in rats

Title
Extracts of oyster mushroom (Pleurotus ostreatus) grown on wheat ameliorate hepatotoxicity induced by carbon tetrachloride in rats
Author(s)
한기동김한섭[김한섭]이종숙[이종숙]정현채[정현채]
Keywords
GERMINATED BROWN RICE; PHELLINUS-LINTEUS; ANTIOXIDANT ACTIVITY; LIVER-INJURY; MODULATION; IGE
Issue Date
201210
Publisher
KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
Citation
FOOD SCIENCE AND BIOTECHNOLOGY, v.21, no.5, pp.1263 - 1267
Abstract
Pleurotus ostreatus (PO), which is also called the oyster mushroom, is the secondly most popular cultivated mushroom in the world and has been shown to display antioxidant activity. In this study, the hepatic protective effects of extracts of PO cultured in wheat (POW) on carbon tetrachloride (CCl4)-induced liver injury in rats were evaluated by analyzing blood markers of liver injury. Sprague-Dawley rats were pretreated with POW extracts (0, 0.5, and 1.0 g/kg) orally for 14 days prior to the administration of CCl4 for 3 days. Marked evaluation of alanine and aspartate aminotransferases, lactate dehydrogenase, alkaline phosphatase, and gamma-glutamyltransferase were observed in the plasma from control rats after CCl4 treatment. This increased liver injury markers were significantly reduced in a dose-dependent manner by pretreatment with the POW extract, suggesting that POW prevented acute liver damage in CCl4-intoxicated rats by suppressing cellular leakage and loss of the functional integrity of cell membranes in the liver. POW extracts could also improve lipid profiles damaged caused by CCl4 in liver through a reducing plasma triglyceride and total cholesterol and a recovering plasma HDL-cholesterol. These results suggest that the extracts of POW ameliorate hepatotoxicity induced by CCl4 in the rat model.
URI
http://hdl.handle.net/YU.REPOSITORY/27159http://dx.doi.org/10.1007/s10068-012-0166-2
ISSN
1226-7708
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자연자원대학 > 식품공학과 > Articles
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