Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don
- Title
- Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don
- Author(s)
- 이승호; 최연호; 주미; 오준석; 나민균[나민균]; 최상길[최상길]; 김동우[김동우]
- Keywords
- TYROSINE-PHOSPHATASE 1B; INSULIN SENSITIVITY; OBESITY; MICE
- Issue Date
- 201210
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.22, no.19, pp.6116 - 6119
- Abstract
- In spite of the critical role of the natural products in drug discovery, surprising little attention has been placed on endangered and rare plant species that could play a pivotal role in pharmaceutical and fiber development. Protein tyrosine phosphatase-1B (PTP1B), which blocks insulin signaling, has been gaining interest to be a promising therapeutic target for the treatment of type 2 diabetes mellitus. Bioassay-guided fractionation on the leaves of Rhododendron brachycarpum G. Don (Ericaceae) yielded seven PTP1B inhibitory triterpenoids, including a new triterpene, rhododendric acid A (1). Their PTP1B inhibitory potency and their lipophilicity were investigated to provide a feasible scaffold that may overcome the innate limitation of the previously reported PTP1B inhibitors. (C) 2012 Elsevier Ltd. All rights reserved.
- URI
- http://hdl.handle.net/YU.REPOSITORY/27153http://dx.doi.org/10.1016/j.bmcl.2012.08.029
- ISSN
- 0960-894X
- Appears in Collections:
- 약학대학 > 약학부 > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML