1,8-cineole protected human lipoproteins from modification by oxidation and glycation and exhibited serum lipid-lowering and anti-inflammatory activity in zebrafish

Title
1,8-cineole protected human lipoproteins from modification by oxidation and glycation and exhibited serum lipid-lowering and anti-inflammatory activity in zebrafish
Author(s)
조경현
Keywords
APOLIPOPROTEIN-A-I; REVERSE CHOLESTEROL TRANSPORT; HIGH-DENSITY-LIPOPROTEIN; TRANSFER PROTEIN-ACTIVITY; ANTIATHEROSCLEROTIC ACTIVITY; PLASMA-LIPOPROTEINS; VITRO; VIVO; EXTRACTS; PEOPLE
Issue Date
201210
Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
Citation
BMB REPORTS, v.45, no.10, pp.565 - 570
Abstract
We recently reported that a water extract of laurel or turmeric, 1,8-cineole enriched fractions, showed hypolipidemic activity in the zebrafish model. Therefore, the present study investigated the cineole's anti-oxidant and anti-inflammatory activities in lipoprotein metabolism in vitro and in vivo. Cineole had inhibitory effects on cupric ion-mediated oxidation of lipoproteins in general, while simultaneously enhancing ferric ion removal ability in high-density lipoprotein (HDL). Hypercholesterolemia was induced in zebrafish using cholesterol-feeding treatment, 4% cholesterol, for 3 weeks. After feeding with or without the addition of cineole, the results revealed that cineole possessed lipid-lowering and anti-inflammatory activities in hypercholesterolemic zebrafish. In addition, serum amyloid A and interleukin-6 levels were lowered and lipid accumulation was decreased in the liver. Conclusively, 1,8-cineole was found to have anti-oxidant activities in lipoprotein metabolism both in vitro and in vivo with simultaneous reduction of lipid accumulation in the liver of zebrafish. [BMB Reports 2012; 45(10): 565-570]
URI
http://hdl.handle.net/YU.REPOSITORY/27146http://dx.doi.org/10.5483/BMBRep.2012.45.10.044
ISSN
1976-6696
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생명공학부 > 생명공학부 > Articles
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