Allogeneic Hematopoietic Stem Cell Transplant for Adults over 40 Years Old with Acquired Aplastic Anemia

Title
Allogeneic Hematopoietic Stem Cell Transplant for Adults over 40 Years Old with Acquired Aplastic Anemia
Author(s)
현명수김혁[김혁]이규형[이규형]윤성수[윤성수]손상건[손상건]주영돈[주영돈]김성현[김성현]김병수[김병수]최정혜[최정혜]곽재용[곽재용]배승화[배승화]신호진[신호진]원종호[원종호]오석중[오석중]이원식[이원식]박재후[박재후]정철원[정철원]
Keywords
BONE-MARROW-TRANSPLANTATION; TOTAL-BODY IRRADIATION; CYCLOPHOSPHAMIDE; FLUDARABINE; REGIMEN; DISEASE; DONORS; AGE
Issue Date
201210
Publisher
ELSEVIER SCIENCE INC
Citation
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, v.18, no.10, pp.1500 - 1508
Abstract
Although younger age is associated with favorable prognosis in adults undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) for aplastic anemia (AA), other pretransplantation factors may be more important than age. We retrospectively analyzed the impact of older age on transplantation outcomes and survival in a total of 225 adult patients with AA who underwent allo-HSCT: 57 patients >40 years old (older patient group [OPG]) and 168 patients <= 40 years old (younger patient group [YPG]). Age at allo-HSCT <= 40 years, time from diagnosis to allo-HSCT <= 6 months, and matched related donor (MRD) were favorable prognostic factors in all study patients. Risk analysis of survival in the OPG showed that age >50 years was the only poor prognostic factor. Survival did not differ significantly between the YPG and patients <50 years old in the OPG. In conclusion, patients between the ages of 41 and 50 years with severe AA and MRDs should undergo allo-HSCT as early as possible to optimize survival. Biol Blood Marrow Transplant 18: 1500-1508 (2012) (C) 2012 American Society fir Blood and Marrow Transplantation
URI
http://hdl.handle.net/YU.REPOSITORY/27136http://dx.doi.org/10.1016/j.bbmt.2012.03.015
ISSN
1083-8791
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의과대학 > 내과학교실 > Articles
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