Predicting outcomes after myocardial infarction by using the Chronic Kidney Disease Epidemiology Collaboration equation in comparison with the Modification of Diet in Renal Disease study equation: results from the Korea Acute Myocardial Infarction Registry

Title
Predicting outcomes after myocardial infarction by using the Chronic Kidney Disease Epidemiology Collaboration equation in comparison with the Modification of Diet in Renal Disease study equation: results from the Korea Acute Myocardial Infarction Registry
Author(s)
김영조최준석[최준석]Chang Seong Kim[Chang Seong Kim]Eun Hui Bae[Eun Hui Bae]Seong Kwon Ma[Seong Kwon Ma]Young-Keun Ahn[Young-Keun Ahn]Myung Ho Jeong[Myung Ho Jeong]Myeong Chan Cho[Myeong Chan Cho]Soo Wan Kim[Soo Wan Kim]Chong Jin Kim[Chong Jin Kim]
Keywords
GLOMERULAR-FILTRATION-RATE; SERUM CREATININE; COCKCROFT-GAULT; ROC CURVE; DYSFUNCTION; MORTALITY; LIMITATIONS; MARKER; AREA
Issue Date
201210
Publisher
OXFORD UNIV PRESS
Citation
NEPHROLOGY DIALYSIS TRANSPLANTATION, v.27, no.10, pp.3868 - 3874
Abstract
Background. The presence of chronic kidney disease is an independent prognostic factor in patients with myocardial infarction (MI). We compared the Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation and the Modification of Diet in Renal Disease (MDRD) study equation with regard to prognostic value in patients with MI. Methods. This study analyzed a retrospective cohort of 11 050 consecutive patients who had MI and were enrolled in the Korea Acute Myocardial Infarction Registry from November 2005 to August 2008. We applied the CKD-EPI equation and the MDRD study equation to determine the estimated glomerular filtration rate (eGFR) in a cohort of patients with MI. Results. The mean eGFR(CKD-EPI) was slightly higher than that of eGFR(MDRD) (73.16 versus 72.23 mL/min/1.73 m(2); P < 0.001). The prevalence of eGFR(CKD-EPI) < 60 mL/min/1.73 m(2) was 26.9%, whereas that of eGFR(MDRD) was 28.5%. The area under the receiver operating characteristic curve was significantly larger for predicting the 1-year major adverse cardiovascular event (MACE) and 1-year all-cause mortality with CKD-EPI equation (0.648 versus 0.641, 0.768 versus 0.753, respectively; P < 0.001). The net reclassification index for improvement in risk of 1-year MACE and 1-year all-cause mortality were 4.09% (P < 0.001) and 9.25% (P < 0.001), respectively. Conclusions. The application of the eGFR(CKD-EPI) demonstrated better predictive values for clinical outcomes than eGFR(MDRD) in a cohort of patients with MI.
URI
http://hdl.handle.net/YU.REPOSITORY/27123http://dx.doi.org/10.1093/ndt/gfs344
ISSN
0931-0509
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의과대학 > 내과학교실 > Articles
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