Full metadata record

DC FieldValueLanguage
dc.contributor.author배영경ko
dc.contributor.author윤길숙[윤길숙]ko
dc.contributor.author이선재[이선재]ko
dc.contributor.author유은실[유은실]ko
dc.contributor.author장기택[장기택]ko
dc.contributor.author김준미[김준미]ko
dc.contributor.author배한익[배한익]ko
dc.contributor.author홍승모[홍승모]ko
dc.date.accessioned2015-12-17T02:08:29Z-
dc.date.available2015-12-17T02:08:29Z-
dc.date.created2015-11-13-
dc.date.issued201210-
dc.identifier.citationKOREAN JOURNAL OF PATHOLOGY, v.46, no.5, pp.415 - 422-
dc.identifier.issn1738-1843-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/27121-
dc.identifier.urihttp://dx.doi.org/10.4132/KoreanJPathol.2012.46.5.415-
dc.description.abstractBackground: Small intestinal adenocarcinomas (SACs) are rare malignancies of the alimentary tract with uncertain carcinogenesis. Methods: We investigated the expression of deleted in pancreatic cancer 4 (DPC4) in 188 cases of surgically resected SACs, using tissue microarray technology. Results: Twenty-four of the 188 tumors showed complete loss of Smad4/DPC4 expression in cytoplasm (score, 0; 12.8%). Eighty-four and 31 cases were moderately and strongly positive, respectively (score, 2 and 3; 44.7% and 16.5%, respectively) and 49 cases were focally or weakly stained (score, 1; 29.1%). Immunohistochemistry analysis showed that the expression of Smad4/DPC4 was related to an increased risk of lymphatic invasion but not to other clinicopathological features of the tumors (tumor location, differentiation, growth pattern, T stage, direct invasion, vascular invasion, and nodal metastasis). There was no significant association between Smad4/DPC4 expression and patient survival. Conclusions: The present research is the first study to evaluate Smad4/DPC4 expression in a large sample of SACs with clinicopathologic correlation. Future studies should focus on the immunohistochemical and molecular characteristics of SACs to clarify their tumorigenesis.-
dc.language영어-
dc.publisherKOREAN SOCIETY PATHOLOGISTS-
dc.subjectTUMOR-SUPPRESSOR GENE-
dc.subjectINACTIVATION-
dc.subjectCARCINOMA-
dc.subjectCANCER-
dc.titleDPC4 Expression in the Small Intestinal Adenocarcinomas-
dc.typeArticle-
dc.identifier.wosid000310715600002-
dc.identifier.scopusid2-s2.0-84873902392-
Appears in Collections:
의과대학 > 병리학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE