DPC4 Expression in the Small Intestinal Adenocarcinomas

Title
DPC4 Expression in the Small Intestinal Adenocarcinomas
Author(s)
배영경윤길숙[윤길숙]이선재[이선재]유은실[유은실]장기택[장기택]김준미[김준미]배한익[배한익]홍승모[홍승모]
Keywords
TUMOR-SUPPRESSOR GENE; INACTIVATION; CARCINOMA; CANCER
Issue Date
201210
Publisher
KOREAN SOCIETY PATHOLOGISTS
Citation
KOREAN JOURNAL OF PATHOLOGY, v.46, no.5, pp.415 - 422
Abstract
Background: Small intestinal adenocarcinomas (SACs) are rare malignancies of the alimentary tract with uncertain carcinogenesis. Methods: We investigated the expression of deleted in pancreatic cancer 4 (DPC4) in 188 cases of surgically resected SACs, using tissue microarray technology. Results: Twenty-four of the 188 tumors showed complete loss of Smad4/DPC4 expression in cytoplasm (score, 0; 12.8%). Eighty-four and 31 cases were moderately and strongly positive, respectively (score, 2 and 3; 44.7% and 16.5%, respectively) and 49 cases were focally or weakly stained (score, 1; 29.1%). Immunohistochemistry analysis showed that the expression of Smad4/DPC4 was related to an increased risk of lymphatic invasion but not to other clinicopathological features of the tumors (tumor location, differentiation, growth pattern, T stage, direct invasion, vascular invasion, and nodal metastasis). There was no significant association between Smad4/DPC4 expression and patient survival. Conclusions: The present research is the first study to evaluate Smad4/DPC4 expression in a large sample of SACs with clinicopathologic correlation. Future studies should focus on the immunohistochemical and molecular characteristics of SACs to clarify their tumorigenesis.
URI
http://hdl.handle.net/YU.REPOSITORY/27121http://dx.doi.org/10.4132/KoreanJPathol.2012.46.5.415
ISSN
1738-1843
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의과대학 > 병리학교실 > Articles
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