Loss of S100A14 Expression Is Associated with the Progression of Adenocarcinomas of the Small Intestine

Title
Loss of S100A14 Expression Is Associated with the Progression of Adenocarcinomas of the Small Intestine
Author(s)
배영경홍승모[홍승모]김광일[김광일]정준용[정준용]전선영[전선영]엄대운[엄대운]장기택[장기택]김지현[김지현]유은실[유은실]
Keywords
SMALL-BOWEL ADENOCARCINOMA; SQUAMOUS-CELL CARCINOMA; COLORECTAL-CANCER; PROTEINS; FAMILY; PATHOGENESIS; TUMORS; ROLES
Issue Date
201210
Publisher
KARGER
Citation
PATHOBIOLOGY, v.80, no.2, pp.95 - 101
Abstract
Objectives: Small intestinal adenocarcinoma (SIAC) is an exceedingly rare human malignant tumor, and its association with the S100A14 gene is not known yet. We aimed to investigate the clinicopathological correlations between S100A14 expression and SIAC. Methods: Immunohistochemical analyses of S100A14, p21 and p53 were performed using tissue microarray analysis of 175 surgically resected SIACs. Results: Of 175 SIACs, loss of S100A14 expression was observed in 128 cases (73.1%). Loss of S100A14 expression was associated with lymph node metastasis (p = 0.009) and advanced disease stage (p = 0.013), and was more frequently observed in distal than duodenal tumors (p = 0.043). The majority of SIACs lost p21 expression (93.7%), and significant loss of p21 expression was observed in cancers with high pT stages (pT 3 and pT 4; p = 0.011), lymph node metastasis (p = 0.029) and advanced cancer stage defined by the American Joint Committee on Cancer (p = 0.005). Overexpression of p53 was found in 23.4% of cases. Positive expression of p53 was associated with distally located SIACs (jejunum or ileum; p = 0.006). There was no association between the expression of S100A14 and p21 or p53. Conclusion: Loss of S100A14 in SIAC is common and is associated with higher metastatic potential and advanced clinical stage. Copyright (C) 2012 S. Karger AG, Basel
URI
http://hdl.handle.net/YU.REPOSITORY/27097http://dx.doi.org/10.1159/000342394
ISSN
1015-2008
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의과대학 > 병리학교실 > Articles
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