Effects of Noscarna (TM) on hypertrophic scarring in the rabbit ear model: Histopathological aspects

Title
Effects of Noscarna (TM) on hypertrophic scarring in the rabbit ear model: Histopathological aspects
Author(s)
용철순김정환트란탄힙김보견[김보견]강민경[강민경]도의선[도의선]장선우[장선우]손미원[손미원]손영택[손영택]최한곤[최한곤]김종오구세광[구세광]조혁준전준호[전준호]한상덕[한상덕]이동원
Keywords
TOPICAL SILICONE GEL; SCARS; MANAGEMENT; HEPARIN; KELOIDS; ALLANTOIN; EPIDERMIS
Issue Date
201211
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.35, no.11, pp.1999 - 2006
Abstract
In this study, we evaluated the effects of silicone-based gel on the healing of hypertrophic scars in the rabbit ear model. After 4-week application of silicone-based gel containing allantoin, dexpanthenol and heparin (Noscarna (TM)) to scars in a rabbit ear model of hypertrophic scarring, significant improvements in hypertrophic scar healing and a great loss of skin pigment were observed compared to the non-treated control, base or silicone control-treated scars. Furthermore, histological analysis of Noscarna (TM)-treated scars revealed a significant reduction in scar elevation index (SEI), anterior skin and epithelial thicknesses, inflammatory cells, vessels, collagen disorganization and fibroblasts compared to all control hypertrophic scars. Furthermore, Noscarna (TM) showed more favorable effects on hypertrophic scars than a commercial product, ContractubexA (R). Therefore, these results clearly demonstrated that the newly developed silicone-based gel, Noscarna (TM), could be a promising formulation as an effective therapeutic agent for hypertrophic scars.
URI
http://hdl.handle.net/YU.REPOSITORY/27002http://dx.doi.org/10.1007/s12272-012-1117-4
ISSN
0253-6269
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약학대학 > 약학부 > Articles
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