Synthesis and anticonvulsant activity of some new series of pyrrole derivatives

Title
Synthesis and anticonvulsant activity of some new series of pyrrole derivatives
Author(s)
아크베르이드하야둘라Jamal Abdul Nasser[Jamal Abdul Nasser]R. Surendra Kumar[R. Surendra Kumar]S. Kavimani[S. Kavimani]Indumathy[Indumathy]
Keywords
1,4-DIHYDROPYRIDINE DERIVATIVES; THIOSEMICARBAZONES; SEMICARBAZONES; KETONES; AGENTS
Issue Date
201211
Publisher
SPRINGER
Citation
MEDICINAL CHEMISTRY RESEARCH, v.21, no.11, pp.3699 - 3708
Abstract
A new series of compounds 3a-f were synthesized from condensation method. Newly synthesized compounds were established by IR, H-1 NMR, C-13 NMR, mass spectral and elemental analysis. Synthesized compounds 3a-f were screened for anticonvulsant activity. The compound 2,2'-({3-methyl-5-[2-phenylethenyl]-1H-pyrrole-2,4-diyl}dicarbonyl)dihydrazinecarbothioamide 3a showed significant activity compared with other compounds 3b-f against pentamethylene tetrazole-induced seizures.
URI
http://hdl.handle.net/YU.REPOSITORY/26988http://dx.doi.org/10.1007/s00044-011-9919-3
ISSN
1054-2523
Appears in Collections:
공과대학 > 화학공학부 > Articles
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