Controlling pH-Regulated Bionanoparticles Translocation through Nanopores with Polyelectrolyte Brushes

Title
Controlling pH-Regulated Bionanoparticles Translocation through Nanopores with Polyelectrolyte Brushes
Author(s)
주상우스즈첸Li-Hsien Yeh[Li-Hsien Yeh]Mingkan Zhang[Mingkan Zhang]Jyh-Ping Hsu[Jyh-Ping Hsu]
Keywords
SOLID-STATE NANOPORES; DNA TRANSLOCATION; ION-TRANSPORT; CHANNELS; SELECTIVITY; MOLECULE; POLARIZATION; ELECTROLYTE; DYNAMICS; PARTICLE
Issue Date
201211
Publisher
AMER CHEMICAL SOC
Citation
ANALYTICAL CHEMISTRY, v.84, no.21, pp.9615 - 9622
Abstract
A novel polyelectrolyte (PE)-modified nanopore, comprising a solid-state nanopore functionalized by a nonregulated PE brush layer connecting two large reservoirs, is proposed to regulate the electrokinetic translocation of a soft nanoparticle (NP), comprising a rigid core covered by a pH-regulated, zwitterionic, soft layer, through it. The type of NP considered mimics bionanoparticles such as proteins and biomolecules. We find that a significant enrichment of H+ occurs near the inlet of a charged solid-state nanopore, appreciably reducing the charge density of the NP as it approaches there, thereby lowering the NP translocation velocity and making it harder to thread the nanopore. This difficulty can be resolved by the proposed PE modified nanopore, which raises effectively both the capture rate and the capture velocity of the soft NP and simultaneously reduces its translocation velocity through the nanopore so that both the sensing efficiency and the resolution are enhanced The results gathered provide a conceptual framework for the interpretation of relevant experimental data and for the design of nanopore-based devices used in single biomolecules sensing and DNA sequencing.
URI
http://hdl.handle.net/YU.REPOSITORY/26973http://dx.doi.org/10.1021/ac302429d
ISSN
0003-2700
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공과대학 > 기계공학부 > Articles
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