Intrahepatic Cholangiocarcinoma With Predominant "Ductal Plate Malformation" Pattern A New Subtype

Title
Intrahepatic Cholangiocarcinoma With Predominant "Ductal Plate Malformation" Pattern A New Subtype
Author(s)
최준혁Yasuni Nakanuma[Yasuni Nakanuma]Yasunori Sato[Yasunori Sato]Hiroko Ikeda[Hiroko Ikeda]Kenichi Harada[Kenichi Harada]MIkiko Kobayashi[MIkiko Kobayashi]Kenji Sano[Kenji Sano]Takeshi Uehara[Takeshi Uehara]Masakazu Yamamoto[Masakazu Yamamoto]Shunichi Ariizumi[Shunichi Ariizumi]Young Nyun Park[Young Nyun Park]Ensil Yu[Ensil Yu]
Keywords
CONGENITAL HEPATIC-FIBROSIS; CAROLIS-DISEASE; CHOLANGIOLOCELLULAR CARCINOMA; BILE-DUCTS; EXPRESSION; PATHOLOGY; PROTEINS; MODEL; RAT
Issue Date
201211
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, v.36, no.11, pp.1629 - 1635
Abstract
Ten cases of intrahepatic cholangiocarcinoma showing a highly differentiated adenocarcinoma mimicking ductal plate malformation (DPM) are reported. The patients included 7 males and 3 females with an average age of 69.5 years. Six cases were associated with chronic liver disease and the remaining 4 cases showed mild fatty change in the parenchyma and/or minimal to mild portal inflammation. Grossly, the tumor was a single nodule 1.5 to 6.6 cm in diameter, and was whitish and solid without a fibrous capsule. Microscopically, the tumor was composed of many vague, small nodular carcinomatous areas with desmoplastic reactions, and neoplastic glands had an irregularly dilated lumen lined with a single layer of cuboidal or low columnar carcinoma cells and irregular protrusions and bulges, resembling DPM. At its border, the carcinoma seemed to replace the non-neoplastic hepatic lobules or regenerative nodules. The central parts of the tumor were variably hypocellular and fibrotic. Although these carcinomas were negative for mucin and HepParI, they were frequently positive for CK19, epithelial cell adhesion molecule, and epithelial membrane antigen. Neural cell adhesion molecule was also expressed variably. The Ki-67 labeling index was < 10% and p53 was scarcely expressed. In conclusion, a new subtype of intrahepatic cholangiocarcinoma with predominant DPM pattern was identified.
URI
http://hdl.handle.net/YU.REPOSITORY/26962http://dx.doi.org/10.1097/PAS.0b013e31826e0249
ISSN
0147-5185
Appears in Collections:
의과대학 > 병리학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE