Safety and Efficacy of Overlapping Homogenous Drug-Eluting Stents in Patients with Acute Myocardial Infarction: Results from Korea Acute Myocardial Infarction Registry

Title
Safety and Efficacy of Overlapping Homogenous Drug-Eluting Stents in Patients with Acute Myocardial Infarction: Results from Korea Acute Myocardial Infarction Registry
Author(s)
김영조Khurshid Ahmed[Khurshid Ahmed]정명호[정명호]Rabin Chakraborty[Rabin Chakraborty]홍영준[홍영준]심두선[심두선]Sumera Ahmed[Sumera Ahmed]황승환[황승환]이민구[이민구]박근호[박근호]김주한[김주한]안영근[안영근]조명찬[조명찬]김정진[김정진]박종찬[박종찬]강정채[강정채]
Keywords
CORONARY-ARTERY-DISEASE; BARE-METAL STENTS; RANDOMIZED CONTROLLED-TRIAL; CLINICAL-TRIALS; IMPLANTATION; METAANALYSIS; LESIONS; INFLAMMATION; RESTENOSIS; THROMBOSIS
Issue Date
201211
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.27, no.11, pp.1339 - 1346
Abstract
The aim of this study was to compare safety and efficacy of 4 homogenous overlapping drug-eluting stents (DES) in acute myocardial infarction (AMI) patients. We selected 1,349 consecutive patients (62.1 +/- 14.9 yr. 69.4% male) who received homogenous overlapping DESs in diffuse de novo coronary lesions from Korea Acute Myocardial Infarction Registry from April 2006 through September 2010. They were divided into 4 groups based on type of DES implanted - Paclitaxel (PES), Sirolimus (SES), Zotarolimus (ZES) and Everolimus (EES)-eluting stents. Primary endpoint was 12-month MACE. We also studied EES versus other DESs (PES + SES + ZES). Mean stent length was 26.2 +/- 7.5 mm and mean stent diameter was 3.1 +/- 0.4 mm. Average number of stents used per vessel was 2.2 +/- 0.5. Incidence of major adverse cardiac events (MACE) in PES, SES, ZES, and EES groups were 9.5%, 9.2%, 7.5%, and 3.8%, respectively (P=0.013). In EES group, overall MACE and repeat revascularization were lowest, and no incidence of stent thrombosis was observed. Non-fatal MI was highest in PES, almost similar in SES and EES with no incidence in ZES group (P=0.044). Cox proportional hazard analysis revealed no differences in the incidence of primary endpoint (P=0.409). This study shows no significant differences in 12-month MACE among 4 groups.
URI
http://hdl.handle.net/YU.REPOSITORY/26961http://dx.doi.org/10.3346/jkms.2012.27.11.1339
ISSN
1011-8934
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의과대학 > 내과학교실 > Articles
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