A Multicenter Study of Pertussis Infection in Adults with Coughing in Korea: PCR-Based Study
- A Multicenter Study of Pertussis Infection in Adults with Coughing in Korea: PCR-Based Study
- 이관호; 장기석[장기석]; 이명구[이명구]; 박영범[박영범]; 유광하[유광하]; 김창환[김창환]; 이영철[이영철]; 권영수[권영수]; 서기현[서기현]; 임성영[임성영]; 박상훈[박상훈]
- Adult; Cough; Incidence; Whooping Cough; Signs and Symptoms
- Issue Date
- Tuberculosis and Respiratory Diseases, v.73, no.5, pp.266 - 272
- Background: Limited data on the incidence and clinical characteristics of adult pertussis infections are available in Korea.
Methods: Thirty-one hospitals and the Korean Centers for Disease Control and Prevention collaborated to investigate the incidence and clinical characteristics of pertussis infections among adults with a bothersome cough in non-outbreak, ordinary outpatient settings. Nasopharyngeal aspirates or nasopharyngeal swabs were collected for polymerase chain reaction (PCR) and culture tests.
Results: The study enrolled 934 patients between September 2009 and April 2011. Five patients were diagnosed as confirmed cases, satisfying both clinical and laboratory criteria (five positive PCR and one concurrent positive culture). Among 607 patients with cough duration of at least 2 weeks, 504 satisfied the clinical criteria of the US Centers for Disease Control and Prevention (i.e., probable case). The clinical pertussis cases (i.e., both probable and confirmed cases) had a wide age distribution (45.7±15.5 years) and cough duration (median, 30 days; interquartile range, 18.0~50.0 days). In addition, sputum, rhinorrhea, and myalgia were less common and dyspnea was more common in the clinical cases, compared to the others (p=0.037, p=0.006, p=0.005, and p=0.030, respectively).
Conclusion: The positive rate of pertussis infection may be low in non-outbreak, ordinary clinical settings if a PCR-based method is used. However, further prospective, well-designed, multicenter studies are needed.
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