Preparation, Characterization, and Release Study of Tacrolimus-Loaded Liquid Crystalline Nanoparticles

Title
Preparation, Characterization, and Release Study of Tacrolimus-Loaded Liquid Crystalline Nanoparticles
Author(s)
유봉규렌가르잔김종오용철순라즈쿠마르타파티아가라쟌
Keywords
ORGAN-TRANSPLANTATION; DELIVERY-SYSTEM; CUBOSOMES; POLYMORPHISMS; CYCLOSPORINE; DISPERSIONS; CYP3A5; FK-506; PHASE; DRUG
Issue Date
201301
Publisher
TAYLOR & FRANCIS INC
Citation
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, v.34, no.1, pp.72 - 77
Abstract
The use of liquid crystalline nanoparticles is a novel approach in the field of controlled drug delivery. Tacrolimus, being a highly lipophilic drug, is easily incorporated in the hydrophobic core of these nanoparticles, which are prepared using monoolein, distilled water, and varying ratios of poloxamer 407. Characterization, including transmission electron microscopy (TEM) images, particle size, and entrapment efficiency analysis suggested the formation of cubosomes with a particle size ranging from 140 to 155 nm and entrapment level of tacrolimus as high as 99% or above. In vitro release studies, revealed a sustained release of tacrolimus for 2 weeks, with a high stability profile of nanoparticles and incorporated drug during the storage period. Therefore, it suggests the possible use of tacrolimus-loaded formulation for intradermal delivery can be useful in the treatment of locally affecting autoimmune skin disease such as psoriasis.
URI
http://hdl.handle.net/YU.REPOSITORY/26872http://dx.doi.org/10.1080/01932691.2011.648462
ISSN
0193-2691
Appears in Collections:
약학대학 > 약학부 > Articles
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