Flavone Reduces the Production of Virulence Factors, Staphyloxanthin and alpha-Hemolysin, in Staphylococcus aureus

Title
Flavone Reduces the Production of Virulence Factors, Staphyloxanthin and alpha-Hemolysin, in Staphylococcus aureus
Author(s)
이진태조무환이진형박주현
Keywords
BIOFILM FORMATION; ESCHERICHIA-COLI; TOXIN
Issue Date
201212
Publisher
SPRINGER
Citation
CURRENT MICROBIOLOGY, v.65, no.6, pp.726 - 732
Abstract
Staphylococcus aureus is a leading cause of nosocomial infections due to its resistance to diverse antibiotics. This bacterium produces a large number of extracellular virulence factors that are closely associated with specific diseases. In this study, diverse plant flavonoids were investigated to identify a novel anti-virulence compound against two S. aureus strains. Flavone, a backbone compound of flavonoids, at subinhibitory concentration (50 mu g/mL), markedly reduced the production of staphyloxanthin and alpha-hemolysin. This staphyloxanthin reduction rendered the S. aureus cells 100 times more vulnerable to hydrogen peroxide in the presence of flavone. In addition, flavone significantly decreased the hemolysis of human red blood by S. aureus, and the transcriptional level of alpha-hemolysin gene hla and a global regulator gene sae in S. aureus cells. This finding supported the usefulness of flavone as a potential antivirulence agent against antibiotic-resistant S. aureus.
URI
http://hdl.handle.net/YU.REPOSITORY/26871http://dx.doi.org/10.1007/s00284-012-0229-x
ISSN
0343-8651
Appears in Collections:
공과대학 > 화학공학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE