Combined Treatment of Betulinic Acid, a PTP1B Inhibitor, with Orthosiphon stamineus Extract Decreases Body Weight in High-Fat-Fed Mice

Title
Combined Treatment of Betulinic Acid, a PTP1B Inhibitor, with Orthosiphon stamineus Extract Decreases Body Weight in High-Fat-Fed Mice
Author(s)
김용운최윤정박소영김종연원규장김보라손종근이승호
Keywords
TYROSINE-PHOSPHATASE 1B; LEPTIN RESISTANCE; SAUSSUREA-LAPPA; CHLOROFORM EXTRACT; OBESE MICE; RATS; EXPRESSION; LACTONE; LEAVES
Issue Date
201301
Publisher
MARY ANN LIEBERT INC
Citation
JOURNAL OF MEDICINAL FOOD, v.16, no.1, pp.2 - 8
Abstract
Leptin resistance is a common feature of obesity and is accompanied by hyperleptinemia. Although leptin sensitizers improve leptin resistance, they also decrease plasma leptin levels that attenuate the leptin-associated antiobesity effect. We hypothesized that the combinational treatment of leptin sensitizer and endogenous leptin expression stimulant would synergistically induce an antiobesity effect in high-fat-fed obese animals. Betulinic acid (BA) isolated from Saussurea lappa suppressed the hypothalamic protein tyrosine phosphatase 1B in mice and enhanced the antiobesity effect of leptin in obese rats. Ethanol extract of Orthosiphon stamineus (OS) induced leptin expressions in both 3T3-L1 adipocytes and mice in a dose-dependent manner. To evaluate our hypothesis, we treated obese mice induced by 6 weeks of high-fat-diet feeding with BA and OS for 2 weeks. Although BA or OS alone did not decrease body weight in obese mice, the combinational treatment of BA and OS decreased body weight significantly compared to either BA- or OS-treated obese mice. These results suggest that combinational treatment of BA and OS would be effective for the treatment of obesity.
URI
http://hdl.handle.net/YU.REPOSITORY/26867http://dx.doi.org/10.1089/jmf.2012.2384
ISSN
1096-620X
Appears in Collections:
의과대학 > 생리학교실 > Articles
의과대학 > 영상의학과학교실 > Articles
의과대학 > 내과학교실 > Articles
약학대학 > 약학부 > Articles
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