Effects of porcine testis extract on wound healing in rat

Title
Effects of porcine testis extract on wound healing in rat
Author(s)
최인호이동목압둘루프바트김용운신동훈김주영김근준[김근준]이기호[이기호]전용필[전용필]전태훈[전태훈]
Keywords
ANABOLIC-STEROIDS; BODY-MASS; OXANDROLONE; PROTEIN; FIBROBLAST; SEPSIS; TRAUMA; INJURY
Issue Date
201212
Publisher
TAYLOR & FRANCIS LTD
Citation
ANIMAL CELLS AND SYSTEMS, v.16, no.6, pp.469 - 478
Abstract
Sex hormones have long been considered to play an important role in bone turnover rate, periodontal diseases, and wound healing. We have studied the effect of porcine testis steroid extract (PTSE), an extract of porcine testes, which holds a good ratio of 19-nortestosterone (nandrolone), testosterone, androstenedione, 17 beta-estradiol, and estrone, on the healing rate of a standardized full-thickness linear wound on the back of the rat. Skin punch or carbon dioxide (CO2) laser methods were used to create the deep skin injury in two groups of animals. The animals were treated with the PTSE cream, control cream and Vaseline (control) to find out the effect in re-epithelialization, contraction, and formation of granulation and scar tissues. Histological examination after 21 days showed 100, 87.4, and 80.5% recovery of epidermis, dermis, and hypodermis, respectively in the PTSE-treated animals. Similarly, on the 15th day of treatment, complete healing of intact skin was observed in the PTSE cream-treated animals among the laser radiation group. Even though the beginning of re-epithelialization phase and completion of serum crust formation was also observed in the base cream-and Vaseline-treated animals respectively, the complete healing cycle was observed only in the PTSE-treated group. The white blood cell count in the PTSE-treated group showed that PTSE cream is nontoxic to animals.
URI
http://hdl.handle.net/YU.REPOSITORY/26863http://dx.doi.org/10.1080/19768354.2012.726645
ISSN
1976-8354
Appears in Collections:
생명공학부 > 생명공학부 > Articles
의과대학 > 생리학교실 > Articles
의과대학 > 피부과학교실 > Articles
의과대학 > 해부학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE