Hormone Receptor Expression in Invasive Breast Cancer Among Korean Women and Comparison of 3 Antiestrogen Receptor Antibodies A Multi-institutional Retrospective Study Using Tissue Microarrays

Title
Hormone Receptor Expression in Invasive Breast Cancer Among Korean Women and Comparison of 3 Antiestrogen Receptor Antibodies A Multi-institutional Retrospective Study Using Tissue Microarrays
Author(s)
배영경공경엽[공경엽]강준[강준]이아원[이아원]조은윤[조은윤]이지신[이지신]서광선[서광선]이동화[이동화]
Keywords
RABBIT MONOCLONAL-ANTIBODY; ESTROGEN-RECEPTOR; IMMUNOHISTOCHEMISTRY; FREQUENCY; SUPERIOR; 1D5
Issue Date
201212
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, v.36, no.12, pp.1817 - 1825
Abstract
Estrogen receptor (ER) and progesterone receptor (PR) are prognostic markers of breast cancer and predictive markers of response to endocrine therapy. To determine rates of ER and PR expression in invasive breast carcinoma among Korean women, the Breast Pathology Study Group of the Korean Society of Pathologists collected 1198 specimens of invasive breast carcinoma from 6 university hospitals. Immunohistochemical analysis was carried out using 1 antibody against PR and 3 antibodies against ER (1D5, 6F11, and SP1). Specimens were evaluated using the semiquantitative Allred score (scores > 2 were considered positive). A total of 1077 cases were interpretable for all 3 anti-ER antibodies. ER expression was positive in 68.5% of cases using SP1, in 59.6% using 1D5, and in 58.9% using 6F11. Of 1073 interpretable cases, PR expression was positive in 51.7% of cases. The frequency distribution of Allred scores revealed a bimodal pattern (complete absence of staining or staining in most cells) for both ER and PR. Patients with discordant results for 2 different ER antibodies showed a median overall survival (between that of double-positive cancer and that of double-negative cancer). Our results showed that the rate of hormone receptor expression in breast carcinomas among Korean patients did not differ from that of western patients. In addition, SP1 was the most sensitive antibody for identifying ER expression in tumors. However, further evaluation is needed to determine which antibody is the best for selecting patients with discordant results who are likely to respond to endocrine therapy.
URI
http://hdl.handle.net/YU.REPOSITORY/26853http://dx.doi.org/10.1097/PAS.0b013e318267b012
ISSN
0147-5185
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의과대학 > 병리학교실 > Articles
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