Role of intestinal microflora in xenobiotic-induced toxicity

Title
Role of intestinal microflora in xenobiotic-induced toxicity
Author(s)
정태천정혜광[정혜광]강미정김형균[김형균]오도경김진성이상규[이상규]
Keywords
HEPG2 CELL-CULTURES; GERM-FREE RATS; ORAL 5-FLUOROURACIL PRODRUGS; FOOD-BORNE CARCINOGEN; IN-VITRO; COLON CARCINOGENESIS; MUTAGENICITY ASSAY; BETA-GLUCURONIDASE; CONVENTIONAL RATS; PROTECTIVE ROLE
Issue Date
201301
Publisher
WILEY-BLACKWELL
Citation
MOLECULAR NUTRITION & FOOD RESEARCH, v.57, no.1, pp.84 - 99
Abstract
In addition to its role in digestion of food in the gastrointestinal tract, the intestinal microflora is also capable of biotransforming numerous drugs. Likewise, the intestinal microflora may significantly modulate xenobiotic-induced toxicity by either activating or inactivating xenobiotics via metabolism. To date, most investigations of xenobiotic metabolism have focused not only on metabolism in host tissues, but the modulation of the pharmacological activity of drugs by the intestinal microflora. Despite its importance, the presumed role of intestinal microflora metabolism in xenobiotic-induced toxicity has been understudied. Therefore, it is appropriate to briefly review our current situation, and state which research in xenobiotic metabolism by intestinal microflora, particularly in the field of toxicology, is needed.
URI
http://hdl.handle.net/YU.REPOSITORY/26843http://dx.doi.org/10.1002/mnfr.201200461
ISSN
1613-4125
Appears in Collections:
약학대학 > 약학부 > Articles
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