A Whole Genome Association Study to Detect Single Nucleotide Polymorphisms for Blood Components (Immunity) in a Cross between Korean Native Pig and Yorkshire

Title
A Whole Genome Association Study to Detect Single Nucleotide Polymorphisms for Blood Components (Immunity) in a Cross between Korean Native Pig and Yorkshire
Author(s)
김종주이윤미아람마부최봉환[최봉환]김관석[김관석]
Keywords
QUANTITATIVE TRAIT LOCI; RESOURCE POPULATION; INTERFERON-GAMMA; CHEMOKINES DARC; SWINE; RESISTANCE/SUSCEPTIBILITY; CYTOKINES; PLATELET; NUMBERS; CHICKS
Issue Date
201212
Publisher
ASIAN-AUSTRALASIAN ASSOC ANIMAL PRODUCTION SOC
Citation
ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, v.25, no.12, pp.1674 - 1680
Abstract
The purpose of this study was to detect significant SNPs for blood components that were related to immunity using high single nucleotide polymorphism (SNP) density panels in a Korean native pig (KNP)xYorkshire (YK) cross population. A reciprocal design of KNP x YK produced 249 F-2 individuals that were genotyped for a total of 46,865 available SNPs in the Illumina porcine 60K beadchip. To perform whole genome association analysis (WGA), phenotypes were regressed on each SNP under a simple linear regression model after adjustment for sex and slaughter age. To set up a significance threshold, 0.1% point-wise p value from F distribution was used for each SNP test. Among the significant SNPs for a trait, the best set of SNP markers were determined using a stepwise regression procedure with the rates of inclusion and exclusion of each SNP out of the model at 0.001 level. A total of 54 SNPs were detected; 10, 6, 4, 4, 5, 4, 5, 10, and 6 SNPs for neutrophil, lymphocyte, monocyte, eosinophil, basophil, atypical lymph, immunoglobulin, insulin, and insulin-like growth factor-I, respectively. Each set of significant SNPs per trait explained 24 to 42% of phenotypic variance. Several pleiotropic SNPs were detected on SSCs 4, 13, 14 and 15.
URI
http://hdl.handle.net/YU.REPOSITORY/26795http://dx.doi.org/10.5713/ajas.2012.12503
ISSN
1011-2367
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생명공학부 > 생명공학부 > Articles
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