Influence of carboxylic acid functionalities in ruthenium (II) polypyridyl complexes on DNA binding, cytotoxicity and antioxidant activity: Synthesis, structure and in vitro anticancer activity

Title
Influence of carboxylic acid functionalities in ruthenium (II) polypyridyl complexes on DNA binding, cytotoxicity and antioxidant activity: Synthesis, structure and in vitro anticancer activity
Author(s)
김석규Thangavel Sathiya Kamatchi[Thangavel Sathiya Kamatchi]Nataraj Chitrapriya[Nataraj Chitrapriya]Frank R. Fronczek[Frank R. Fronczek]Karuppannan Natarajan[Karuppannan Natarajan]
Keywords
DEOXYRIBONUCLEIC-ACID; TRANSCRIPTION INHIBITION; SEQUENCE SELECTIVITY; ANCILLARY LIGANDS; ANTITUMOR AGENTS; AFFINITY; MODE; INTERCALATION; REDOX; DERIVATIVES
Issue Date
201301
Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Citation
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.59, pp.253 - 264
Abstract
Four new Ru(II) complexes [RuHCl(bpy)(PPh3)(CO)] (1), [RuHCl(bpy)(AsPh3)(CO)] (2) (bpy = 2,2'-bipyridine), [RuCl(HL)(PPh3)(2)(CO)] (3) and [RuCl(HL)(AsPh3)(2)(CO)] (4) (HL = 2,2'-bipyridine-4,4'-dicarboxylic acid) were synthesized and characterized. X-ray diffraction was used to characterize 3 in solid state. The interactions of these complexes with DNA were explored by different techniques which revealed that the complexes could bind to CT-DNA through non-intercalation. The in vitro cytotoxic and antioxidant activities of the complexes validated against a panel of cancer cell lines and free radicals showed that 3 and 4 possess quite high anticancer and antioxidant activities over 1, 2 and standard drugs. An apparent dependence of biological activities on incorporation of COOH in bipyridine moiety was noticed: Inclusion of COOH caused significant differences in DNA binding, cytotoxicity and antioxidant activity. (C) 2012 Elsevier Masson SAS. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/26787http://dx.doi.org/10.1016/j.ejmech.2012.11.024
ISSN
0223-5234
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이과대학 > 화학생화학부 > Articles
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