Clinical outcomes between different stent designs with the same polymer and drug: comparison between the Taxus Express and Taxus Liberte stents

Title
Clinical outcomes between different stent designs with the same polymer and drug: comparison between the Taxus Express and Taxus Liberte stents
Author(s)
박종선손장원김웅김영조장재식[장재식]양태현[양태현]김동수[김동수]김동기[김동기]설상훈[설상훈]김두일[김두일]남창욱[남창욱]허승호[허승호]김권배 [김권배 ]
Keywords
PACLITAXEL-ELUTING STENT; SMALL CORONARY-ARTERIES; ISAR-STEREO TRIAL; SLOW-RELEASE; STRUT THICKNESS; DOUBLE-BLIND; LESIONS; RESTENOSIS; RISK
Issue Date
201301
Publisher
KOREAN ASSOC INTERNAL MEDICINE
Citation
KOREAN JOURNAL OF INTERNAL MEDICINE, v.28, no.1, pp.72 - 80
Abstract
Background/Aims: The Taxus Liberte stent (Boston Scientific Co.) evolved from the Taxus Express stent, with enhanced stent deliverability and uniform drug delivery. This study was designed to compare angiographic and clinical outcomes in real-world practice between the Taxus Liberte and Taxus Express stents. Methods: Between 2006 and 2008, 240 patients receiving the Taxus Liberte stent at three centers were registered and compared to historical control patients who had received the Taxus Express stent (n = 272). After propensity score matching, 173 patients treated with the Taxus Liberte stent and the same number of patients treated with the Taxus Express stent were selected. The primary outcome was a composite of major adverse cardiac events (MACE), including cardiac death, myocardial infarction (MI), ischemia driven target vessel revascularization (TVR), and stent thrombosis (ST) at 1 year. An additional angiographic assessment was conducted at 9 to 12 months. Results: The study showed no significant difference between the Taxus Express and Taxus Liberte stents (death, 1.73% vs. 2.31%, p = 1.000; MI, o% vs. 1.73%, p = 0.2478; TVR, 2.31% vs. 1.16%, p = 0.6848; and ST, o% vs. 1.16%, p = 0.4986). The total MACE rate at 1 year did not differ between the groups (4.05% in Taxus Express vs. 4.05% in Taxus Liberte, p = 1.000). In addition, the binary restenosis rate did not differ (2.25% in Taxus Express vs. 1.80% in Taxus Liberte, p = 0.6848). Conclusions: In real-world experience with the two Taxus stent designs, both stents showed similarly good clinical and angiographic outcomes at 1 year. A long-term follow-up study is warranted.
URI
http://hdl.handle.net/YU.REPOSITORY/26786http://dx.doi.org/10.3904/kjim.2013.28.1.72
ISSN
1226-3303
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의과대학 > 내과학교실 > Articles
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