Methionine sulfoxide reductase A attenuates heme oxygenase-1 induction through inhibition of Nrf2 activation

Title
Methionine sulfoxide reductase A attenuates heme oxygenase-1 induction through inhibition of Nrf2 activation
Author(s)
김화영김정연최승희이유진강영진
Keywords
OXIDATIVE STRESS; ANTIOXIDANT RESPONSE; MOLECULAR-MECHANISMS; CONFERS RESISTANCE; CELLS; OVEREXPRESSION; PROLIFERATION; EXPRESSION; PROTECTS; P21
Issue Date
201212
Publisher
ELSEVIER SCIENCE INC
Citation
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, v.528, no.2, pp.134 - 140
Abstract
Methionine sulfoxide reductase A (MsrA) functions as a protein repair enzyme by catalyzing the stereospecific reduction of methionine-S-sulfoxide to methionine. We previously identified that MsrA deficiency inhibits normal cell growth via activation of the p53-p21 pathway. In this study, we report a critical role of MsrA in expression of heme oxygenase-1 (HO-1), a highly inducible enzyme that has an anti-proliferative effect mediated by up-regulation of p21. Down-regulation of MsrA induced HO-1 expression in mammalian cells with increased p21 levels, but MsrA overexpression did not affect HO-1 expression. MsrA depletion activated Nrf2 by increasing its expression and nuclear translocation. Nrf2 activation was associated with increased reactive oxygen species production. MsrA overexpression in MsrA-depleted cells led to the reduction of increased HO-1 expression, and suppressed nuclear accumulation of Nrf2. Taken together, the data suggest that MsrA attenuates HO-1 induction by inhibiting Nrf2 activation. (C) 2012 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/26781http://dx.doi.org/10.1016/j.abb.2012.09.012
ISSN
0003-9861
Appears in Collections:
의과대학 > 생화학.분자생물학교실 > Articles
의과대학 > 영상의학과학교실 > Articles
의과대학 > 약리학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE