Effect of Methylphenidate on Sleep Parameters in Children with ADHD

Title
Effect of Methylphenidate on Sleep Parameters in Children with ADHD
Author(s)
서완석이상헌성형모[성형모]최태영[최태영]김소연[김소연]최소정[최소정]구본훈이종훈[이종훈]
Keywords
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; TRANSDERMAL METHYLPHENIDATE; SCHOOL-CHILDREN; PHARMACOKINETICS; SCHIZOPHRENIA; RESTRICTION; RELIABILITY; MANAGEMENT; SCHEDULE
Issue Date
201212
Publisher
KOREAN NEUROPSYCHIATRIC ASSOC
Citation
PSYCHIATRY INVESTIGATION, v.9, no.4, pp.384 - 390
Abstract
Objective The primary aim of this study was to investigate the acute impact of methylphenidate (MPH) on sleep parameters in attention-deficit/hyperactivity disorder (ADHD) children. The second aim was to investigate the different effects of intermediate- and long-acting MPH on sleep parameters. The third aim was to test the different effects of dose and age on sleep parameters. Methods Ninety-three ADHD children were enrolled and randomized to two different MPH preparations. Baseline and daily sleep diaries were evaluated for four weeks after taking medication. Weekday and weekend bedtimes, wake-up times, sleep latencies and total sleep times were compared by weeks. Results After taking MPH, there was a significant delay in bedtimes and a significant reduction of total sleep time (TST) both on weekdays and at weekends. There was also a significant delay in wake-up time on weekdays. However, the difference was applied to younger age group children only. There was no difference in changes of TST between metadate-CD and OROS-MPH. There also was no difference in changes of TST with different doses of MPH. Conclusion MPH had negative impacts on sleep among young ADHD children, but different preparations and doses did not affect the result. Psychiatry Investig 2012;9:384-390
URI
http://hdl.handle.net/YU.REPOSITORY/26760http://dx.doi.org/10.4306/pi.2012.9.4.384
ISSN
1738-3684
Appears in Collections:
의과대학 > 정신건강의학교실 > Articles
의과대학 > 영상의학과학교실 > Articles
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