Heterologous Production of 4-O-Demethylbarbamide, a Marine Cyanobacterial Natural Product

Title
Heterologous Production of 4-O-Demethylbarbamide, a Marine Cyanobacterial Natural Product
Author(s)
김은지[김은지]이종현[이종현]최혁재Alban R. Pereira[Alban R. Pereira]Yeon Hee Ban[Yeon Hee Ban]Young Ji Yoo[Young Ji Yoo]Eunji Kim[Eunji Kim]Je Won Park[Je Won Park]David H. Sherman[David H. Sherman]William H. Gerwick[William H. Gerwick]Yeo Joon Yoon[Yeo Joon Yoon]
Keywords
STREPTOMYCES-VENEZUELAE; LYNGBYA-MAJUSCULA; BARBAMIDE BIOSYNTHESIS; POLYKETIDE SYNTHASE; DRUG DISCOVERY; FUTURE; METABOLITE; EXPRESSION; DIVERSITY; MACROLIDE
Issue Date
201212
Publisher
AMER CHEMICAL SOC
Citation
ORGANIC LETTERS, v.14, no.23, pp.5824 - 5827
Abstract
Heterologous expression of the barbamide biosynthetic gene cluster, obtained from the marine cyanobacterium Moorea producens, in the terrestrial actinobacterium Streptomyces venezuelae, resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the potential of this approach for investigating the assembly and tailoring of complex marine natural products.
URI
http://hdl.handle.net/YU.REPOSITORY/26739http://dx.doi.org/10.1021/ol302575h
ISSN
1523-7060
Appears in Collections:
약학대학 > 약학부 > Articles
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