Retrograde Versus Antegrade Nerve Sparing During Robot-assisted Radical Prostatectomy: Which Is Better for Achieving Early Functional Recovery?

Title
Retrograde Versus Antegrade Nerve Sparing During Robot-assisted Radical Prostatectomy: Which Is Better for Achieving Early Functional Recovery?
Author(s)
고영휘Patel, Vipul R.[Patel, Vipul R.]Coelho, Rafael F.[Coelho, Rafael F.]Sivaraman, Ananthakrishnan[Sivaraman, Ananthakrishnan]Schatloff, Oscar[Schatloff, Oscar]Chauhan, Sanket[Chauhan, Sanket]Abdul-Muhsin, Haidar M.[Abdul-Muhsin, Haidar M.]Carrion, Rair Jose Valero[Carrion, Rair Jose Valero]Palmer, Kenneth J.[Palmer, Kenneth J.]Cheon, Jun[Cheon, Jun]
Keywords
SEXUAL FUNCTION; RETROPUBIC PROSTATECTOMY; SURGICAL TECHNIQUE; CONTINENCE; PRESERVATION; OUTCOMES; SURGEON; QUALITY; FASCIA
Issue Date
201301
Publisher
ELSEVIER SCIENCE BV
Citation
EUROPEAN UROLOGY, v.63, no.1, pp.169 - 177
Abstract
Background: Although the retrograde approach to nerve sparing (NS) aimed at maximizing NS during robot-assisted radical prostatectomy (RARP) has been described, its significant benefits compared to the antegrade approach have not yet been investigated. Objective: To evaluate the impact of NS approaches on perioperative, pathologic, and functional outcomes. Design, setting, and participants: Five hundred one potent (Sexual Health Inventory for Men [SHIM] score >21) men underwent bilateral full NS and were followed up for a minimum of 1 yr. After propensity score matching, 344 patients were selected and were then categorized into two groups. Surgical procedure: RARP with antegrade NS (n = 172) or RARP with retrograde NS (n = 172). Outcome measurements and statistical analysis: Functional outcomes were assessed using validated questionnaires. Multivariable logistic regression models were applied. Results and limitations: Positive margin rates were similar (11.1% vs 6.9%; p = 0.192), and no correlation with the NS approach was found on regression analysis. At 3, 6, and 9 mo, the potency rate was significantly higher in the retrograde approach (65% vs 80.8% and 72.1% vs 90.1% and 85.3% vs 92.9%, respectively). The multivariable model indicated that the NS approach was an independent predictor for potency recovery at 3, 6, and 9 mo, along with age, gland size, and hyperlipidemia. After adjusting for these predictors, the hazard ratio (HR) for the retrograde relative to the antegrade approach was 2.462 (95% confidence interval [CI], 1.482-4.089; p = 0.001) at 3, 4.024 (95% CI, 2.171-7.457; p < 0.001) at 6, and 2.145 (95% CI, 1.019-4.514; p = 0.044) at 9 mo. Regarding continence, the recovery rates at each time point and the mean time to regaining it were similar, and the method of NS had no effect on multivariable analysis. The absence of randomization is a major limitation of this study. Conclusions: In patients with normal erectile function who underwent bilateral full NS, a retrograde NS approach facilitated early recovery of potency compared to that with an antegrade NS approach without compromising cancer control. (C) 2012 Published by Elsevier B. V. on behalf of European Association of Urology.
URI
http://hdl.handle.net/YU.REPOSITORY/26735http://dx.doi.org/10.1016/j.eururo.2012.09.051
ISSN
0302-2838
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의과대학 > 비뇨기과학교실 > Articles
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