Automatic differential diagnosis of pancreatic serous and mucinous cystadenomas based on morphological features

Title
Automatic differential diagnosis of pancreatic serous and mucinous cystadenomas based on morphological features
Author(s)
최준혁이주홍[이주홍]전석주[전석주]송재원[송재원]
Keywords
IMAGE-ANALYSIS; CYSTIC TUMORS; BREAST; PROSTATE; SEGMENTATION
Issue Date
201301
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
COMPUTERS IN BIOLOGY AND MEDICINE, v.43, no.1, pp.1 - 15
Abstract
Generally, pathological diagnosis using an electron microscope is time-consuming and likely to result in a subjective judgment, because pathologists perform manual screening of tissue slides at high magnifications. Recently, the advent of digital pathology technology has provided the basis for convenient screening and quantitative analysis by digitizing tissue slides through a computer system. However, a screening process with high magnification still takes quite a long time. To solve these problems, recently the use of computer-aided design techniques for performing pathologic diagnosis has been increasing in digital pathology. For pathological diagnosis, we need different diagnostic methods for different regions with different characteristics. Therefore, in order to effectively diagnose different lesions and types of diseases, a quantitative method for extracting specific features is required in computerized pathologic diagnosis. This study is about an automated differential diagnosis system to differentiate between benign serous cystadenoma and possibly-malignant mucinous cystadenoma. In order to diagnose cystic tumors, the first step is identifying a cystic region and inspecting its epithelial cells. First, we identify the lumen boundary of a cyst using the Direction Cumulative Map considering 8-ways. Then, the Epithelial Nuclei Identification algorithm is used to discern epithelial nuclei. After that, three morphological features for the differential diagnosis of mucinous and serous cystadenomas are extracted. To demonstrate the superiority of the proposed features, the experiments compared performance of the classifiers learned by using the proposed morphological features and the classical morphological features based on nuclei. The classifiers in the simulations are as follows; Bayesian Classifier, k-Nearest Neighbors, Support Vector Machine, and Artificial Neural Network. The results show that all classifiers using the proposed features have the best classification performance. (C) 2012 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/26734http://dx.doi.org/10.1016/j.compbiomed.2012.10.009
ISSN
0010-4825
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의과대학 > 병리학교실 > Articles
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