Difference of neural connectivity for motor function in chronic hemiparetic stroke patients with intracerebral hemorrhage

Title
Difference of neural connectivity for motor function in chronic hemiparetic stroke patients with intracerebral hemorrhage
Author(s)
장성호권용현[권용현]이미영[이미영]이동엽[이동엽]홍지헌[홍지헌]
Keywords
DIFFUSION TENSOR TRACTOGRAPHY; CORTICOSPINAL TRACT; MOVEMENT KINEMATICS; LONGITUDINAL FMRI; HUMAN BRAIN; RECOVERY; CORTEX; REORGANIZATION; HEMISPHERE; DISCHARGE
Issue Date
201212
Publisher
ELSEVIER IRELAND LTD
Citation
NEUROSCIENCE LETTERS, v.531, no.2, pp.80 - 85
Abstract
Difference of neural connectivity for motor function had been studied by observation of neural activity within gray matter and nucleus using functional neuroimaging techniques. Diffusion tensor imaging (DTI) by a probabilistic tracking is useful for exploration of structural connectivity in the brain. We attempted to investigate difference of neural connectivity for motor function of the affected hand in chronic hemiparetic patients with intracerebral hemorrhage (ICH). Forty-four patients with ICH and 31 normal control subjects were recruited. Diffusion tensor imaging was acquired using a sensitivity-encoding head coil at 1.5T. Motor function was evaluated using the motricity index (MI) for hand and Modified Brunnstrom Classification (MBC). The presence or absence of a connection was confirmed between the precentral knob of the affected hemisphere and seven areas. Compared with healthy subjects, the patient group showed lower connectivity to the contralesional primary motor cortex, ipsilesional basal ganglia, ipsilesional thalamus, contralesional cerebellum, and ipsilesional medullary pyramid in the affected hemisphere (p<0.05). Connections to the ipsilesional basal ganglia, ipsilesional thalamus, and ipsilesional medullary pyramid showed positive correlation with MI and MBC (p<0.05). We found difference of neural connectivity for motor function between chronic hemiparetic patients with ICH and control subjects. Our results suggest that the motor function of the stroke patient is related to neural connectivity between the ipsilesional M1 and the ipsilesional medullary pyramid, ipsilesional basal ganglia, and ipsilesional thalamus. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/26699http://dx.doi.org/10.1016/j.neulet.2012.10.026
ISSN
0304-3940
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의과대학 > 재활의학교실 > Articles
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