PYRIN domains and their interactions in the apoptosis and inflammation signaling pathway

Title
PYRIN domains and their interactions in the apoptosis and inflammation signaling pathway
Author(s)
박현호
Keywords
DEATH-EFFECTOR DOMAIN; CRYSTAL-STRUCTURE; NMR STRUCTURE; 3-DIMENSIONAL STRUCTURE; NALP3 INFLAMMASOME; STRUCTURAL BASIS; INNATE-IMMUNITY; CELL-DEATH; PROTEIN; COMPLEX
Issue Date
201212
Publisher
SPRINGER
Citation
APOPTOSIS, v.17, no.12, pp.1247 - 1257
Abstract
The PYRIN domain (PYD) is a well known protein interaction module and a prime mediator of the protein interactions necessary for apoptosis, inflammation and innate immune signaling pathway. Because PYD-mediated apoptosis, inflammation and innate immune processes are associated with many human diseases, studies in these areas are of great biological importance. Intensive biochemical and structural studies of PYD have been conducted in the past decade to elucidate PYD-mediated signaling events, and evaluations of the molecular structure of PYDs have shown the underlying molecular basis for the assembly of PYD-mediated complexes and for the regulation of inflammation and innate immunity. This review summarizes the structure and function of various PYDs and proposes a PYD:PYD interaction for assembly of the complexes involved in those signaling pathways.
URI
http://hdl.handle.net/YU.REPOSITORY/26696http://dx.doi.org/10.1007/s10495-012-0775-5
ISSN
1360-8185
Appears in Collections:
이과대학 > 화학생화학부 > Articles
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