Inhibitory Effect of Ethanol Extract of Magnolia officinalis on Memory Impairment and Amyloidogenesis in a Transgenic Mouse Model of Alzheimer's Disease via Regulating beta-Secretase Activity

Title
Inhibitory Effect of Ethanol Extract of Magnolia officinalis on Memory Impairment and Amyloidogenesis in a Transgenic Mouse Model of Alzheimer's Disease via Regulating beta-Secretase Activity
Author(s)
최동영이영중[이영중]한상배[한상배]김형희[김형희]황방연[황방연]강종구[강종구]이범준[이범준]오기완[오기완]홍진태[홍진태]김기호[김기호]
Keywords
AMYLOID PRECURSOR PROTEIN; OXIDATIVE STRESS; A-BETA; ANTIINFLAMMATORY ACTIVITY; HONOKIOL; MICE; BRAIN; 4-O-METHYLHONOKIOL; PLAQUES; DAMAGE
Issue Date
201212
Publisher
WILEY-BLACKWELL
Citation
PHYTOTHERAPY RESEARCH, v.26, no.12, pp.1884 - 1892
Abstract
Alzheimer's disease (AD) is the most common form of dementia and is characterized by deposition of amyloid beta (A beta) in the brain. The components of the herb Magnolia officinalis are known to have antiinflammatory, antioxidative and neuroprotective activities. In this study we investigated the effects of ethanol extract of M. officinalis on memory dysfunction and amyloidogenesis in a transgenic mouse model of AD. Oral pretreatment of ethanol extract of M. officinalis (10?mg/kg in 0.05% ethanol) into drinking water for 3?months inhibited memory impairment and A beta deposition in the brain of Tg2576 mice. Ethanol extract of M. officinalis also decreased activity of beta-secretase, cleaving A beta from amyloid precursor protein (APP), and expression of beta-site APP cleaving enzyme 1 (BACE1), APP and its product, C99. Our results showed that ethanol extract of M. officinalis effectively prevented memory impairment via down-regulating beta-secretase activity. Copyright (c) 2012 John Wiley & Sons, Ltd.
URI
http://hdl.handle.net/YU.REPOSITORY/26692http://dx.doi.org/10.1002/ptr.4643
ISSN
0951-418X
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약학대학 > 약학부 > Articles
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