Wound healing evaluation of benzalkonium chloride-loaded hydrocolloid in the wound infection model

Title
Wound healing evaluation of benzalkonium chloride-loaded hydrocolloid in the wound infection model
Author(s)
김종오김정환진성규[진성규]최한곤[최한곤]구세광[구세광]손영택[손영택]남두현용철순류동성[류동성]도의선[도의선]장선우[장선우]손미원[손미원]
Keywords
Benzalkonium chloride; Hydrocolloid; Wound dressing; Wound healing
Issue Date
201212
Publisher
한국약제학회
Citation
Journal of Pharmaceutical Investigation, v.42, no.6, pp.327 - 333
Abstract
An adequate environment for wound healing improves cell proliferation and cell activity, rearranges fibroblasts, and suppresses the multiplication of bacteria. The aim of this study was to evaluate the wound-healing effects of a semi-occlusive hydrocolloid wound dressing (HWD) containing a topical antiseptic drug, benzalkonium chloride (BKC) in an infectious wound model. In vivo wound-healing profiles in rats exhibited that BKC-loaded HWD successfully promoted epithelialization rate, compared with gauze control or HWD without BKC. Furthermore,the significant decrease in desquamated epithelial regions, numbers of microvessels and inflammatory cells infiltrated in granulation tissues and granulation tissue areas were observed in the histopathological and histomorphometrical profiles of BKC-loaded HWD. In conclusion,these results suggest that BKC-loaded HWD facilitates wound healing and re-epithelization, and has promising effects for the treatment of infected wounds, as compared to HWD without BKC.
URI
http://hdl.handle.net/YU.REPOSITORY/26604
ISSN
2093-5552
Appears in Collections:
약학대학 > 약학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE