Attenuation of Spinal Cord Injury-Induced Astroglial and Microglial Activation by Repetitive Transcranial Magnetic Stimulation in Rats

Title
Attenuation of Spinal Cord Injury-Induced Astroglial and Microglial Activation by Repetitive Transcranial Magnetic Stimulation in Rats
Author(s)
안상호김지영최규식조윤우조희경황세진[황세진]
Keywords
CHRONIC NEUROPATHIC PAIN; MOTOR CORTEX RTMS; GLIAL ACTIVATION; CONTUSION MODEL; COLD ALLODYNIA; CHRONIC STROKE; EXPRESSION; PATHWAYS; BEHAVIOR; BRAIN
Issue Date
201302
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.28, no.2, pp.295 - 299
Abstract
Spinal cord injury (SCI) causes not only loss of sensory and motor function below the level of injury but also chronic pain, which is difficult and challenging of the treatment. Repetitive transcranial magnetic stimulation (rTMS) to the motor cortex, of non-invasive therapeutic methods, has the motor and sensory consequences and modulates pain in SCI-patients. In the present study, we studied the effectiveness of rTMS and the relationship between the modulation of pain and the changes of neuroglial expression in the spinal cord using a rat SCI-induced pain model. Elevated expressions of Iba1 and GFAP, specific microglial and astrocyte markers, was respectively observed in dorsal and ventral horns at the L4 and L5 levels in SCI rats. But in SCI rats treated with 25 Hz rTMS for 8 weeks, these expressions were significantly reduced by about 30%. Our finding suggests that this attenuation of activation by rTMS is related to pain modulation after SCI. Therefore, rTMS might provide an alternative means of attenuating neuropathic pain below the level of SCI.
URI
http://hdl.handle.net/YU.REPOSITORY/26582http://dx.doi.org/10.3346/jkms.2013.28.2.295
ISSN
1011-8934
Appears in Collections:
의과대학 > 재활의학교실 > Articles
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