Lycopene supplementation suppresses oxidative stress induced by a high fat diet in gerbils

Title
Lycopene supplementation suppresses oxidative stress induced by a high fat diet in gerbils
Author(s)
서정숙최수경
Keywords
IN-VIVO; GLUTATHIONE PEROXIDASE; LIPID-PEROXIDATION; ANTIOXIDANT STATUS; TOMATO LYCOPENE; ANIMAL-TISSUES; BETA-CAROTENE; RATS; ACID; OBESITY
Issue Date
201302
Publisher
KOREAN NUTRITION SOC
Citation
NUTRITION RESEARCH AND PRACTICE, v.7, no.1, pp.26 - 33
Abstract
The effect of lycopene supplementation on the antioxidant system was investigated by analyzing lipid peroxide levels, glutathione contents, and antioxidant enzyme activities in Mongolian gerbils fed a high fat diet. Gerbils were fed on each experimental diet for 6 weeks; normal diet (NC), normal diet with 0.05% lycopene (NL), high fat diet (HF), and a high fat diet with 0.05% lycopene (HFL). Dietary supplementation of lycopene increased hepatic lycopene level in gerbils fed a normal or high fat diet (P < 0.05). Liver and erythrocyte concentrations of lipid peroxide increased in gerbils fed a high fat diet, whereas lycopene supplementation decreased liver and erythrocyte concentrations of lipid peroxide (P < 0.05). Hepatic total glutathione content was higher in the NL group than that in the NC group (P < 0.05). Total antioxidant status in plasma increased following lycopene supplementation compared with that of the non-lycopene supplemented groups (P < 0.05). Hepatic catalase activity increased following dietary lycopene supplementation (P < 0.05). Superoxide dismutase activity in liver remained unchanged with lycopene supplementation, but erythrocyte superoxide dismutase activity increased in NL group compared with NC group (P < 0.05). Glutathione-S-transferase activity increased in the NL group compared to NC group (P < 0.05). Liver and erythrocyte glutathione peroxidase activity increased significantly in the NL group compared to that in the HF group (P < 0.05). Liver glutathione reductase activity was higher in the NL group than that in the NC group (P < 0.05). These results suggest that lycopene supplementation may be efficient for preventing chronic diseases induced by oxidative stress related to high fat diet.
URI
http://hdl.handle.net/YU.REPOSITORY/26439http://dx.doi.org/10.4162/nrp.2013.7.1.26
ISSN
1976-1457
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생활과학대학 > 식품영양학과 > Articles
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