Combined Loss of E-cadherin and Aberrant beta-Catenin Protein Expression Correlates With a Poor Prognosis for Small Intestinal Adenocarcinomas

Title
Combined Loss of E-cadherin and Aberrant beta-Catenin Protein Expression Correlates With a Poor Prognosis for Small Intestinal Adenocarcinomas
Author(s)
배영경홍승모[홍승모]이희진[이희진]이옥준[이옥준]장기택[장기택]정준용[정준용]엄대운[엄대운]김준미[김준미]유은실[유은실]
Keywords
PANCREATIC INTRAEPITHELIAL NEOPLASIA; SMALL-BOWEL; IMMUNOHISTOCHEMICAL ANALYSIS; CARCINOMAS; CANCER; MUTATIONS; PATHOGENESIS; ACTIVATION; PHENOTYPE; DELETIONS
Issue Date
201302
Publisher
AMER SOC CLINICAL PATHOLOGY
Citation
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, v.139, no.2, pp.167 - 176
Abstract
Small intestinal adenocarcinomas (SLACs) are rare, and their molecular pathogenesis is largely unknown. To define the roles of E-cadherin and beta-catenin, we performed immunohistochemistry for E-cadherin and beta-catenin in 194 surgically resected SIACs with tissue microarrays and compared the data with clinicopathologic factors, including survival rates of patients with SIAC. Loss of E-cadherin expression and aberrant beta-catenin expression were observed in 41.8% (81/194 cases) and 40.7% (79/194 cases) of SIACs, respectively. Combined loss of E-cadherin and aberrant beta-catenin expression was observed in 24.2% (47/194 cases) of SIACs, and this feature was most frequently observed in mucinous adenocarcinomas and signet ring cell carcinomas (P < .001), poorly differentiated and undifferentiated carcinomas (P < .001), and tumors with advanced pT classification (P = .03). Survival times for patients with SIAC with both loss of E-cadherin and aberrant beta-catenin expression (median, 13.9 months) were significantly shorter than those for patients without aberrant expression of both proteins (49.9 months), as determined by univariate (P < .001) and multivariate (P = .01) analyses. In conclusion, loss of E-cadherin and aberrant beta-catenin expression correlate with poorly differentiated tumors, advanced T classification, and decreased patient survival time; therefore, it could be a prognostic factor in patients with SIAC.
URI
http://hdl.handle.net/YU.REPOSITORY/26407http://dx.doi.org/10.1309/AJCPS54RTFCTHGWX
ISSN
0002-9173
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의과대학 > 병리학교실 > Articles
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