Effect of Early Statin Treatment in Patients with Cardiogenic Shock Complicating Acute Myocardial Infarction
- Effect of Early Statin Treatment in Patients with Cardiogenic Shock Complicating Acute Myocardial Infarction
- 김영조; 심두선[심두선]; 정명호[정명호]; 조경훈[조경훈]; 안영균[안영균]; 홍탁정[홍탁정]; 김종진[김종진]; 조명찬[조명찬]; 배정호[배정호]
- Angioplasty; Myocardial infarction; Shock.
- Issue Date
- Korean Circulation Journal, v.43, no.2, pp.100 - 109
- Background and Objectives: The benefit of early statin treatment following acute myocardial infarction (MI) complicated with cardio -genic shock (CS) has not been well studied. We sought to assess the effect of early statin therapy in patients with CS complicating acute MI.
Subjects and Methods: We studied 553 statin-naïve patients with acute MI and CS (Killip class IV) who underwent revascularization therapy between November 2005 and January 2008 at 51 hospitals in the Korea Acute Myocardial Infarction Registry. Patients were di-vided into 2 groups: those who received statins during hospitalization (n=280) and those who did not (n=273). The influence of statin treatment on a 12-month clinical outcome was examined using a matched-pairs analysis (n=200 in each group) based on the propensity for receiving statin therapy during hospitalization.
Results: Before adjustment, patients receiving statin, compared to those not receiving statin, had a more favorable clinical profile, were less likely to suffer procedural complications, and more likely to receive adequate medical therapy. Patients receiving statin had lower un-adjusted in-hospital mortality and composite rate of mortality, MI, and repeat revascularization at 12 months, which remained signifi-cantly lower after adjustment for patient risk, procedural characteristics, and treatment propensity.
Conclusion: In CS patients with acute MI undergoing revascularization therapy, early statin treatment initiated during hospitalization was associated with lower rates of in-hospital death and 12-month adverse cardiac events.
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