Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery

Title
Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery
Author(s)
김종오티아가라쟌렌가르잔라즈쿠마르타파류정연최혜윤유봉규[유봉규]용철순
Keywords
DRUG-DELIVERY; SKIN PENETRATION; CYCLOSPORINE-A; HAIR-GROWTH; ANDROGENETIC ALOPECIA; PHOTODYNAMIC THERAPY; PROPYLENE-GLYCOL; PHASES; MONOOLEIN; RELEASE
Issue Date
201303
Publisher
SPRINGER
Citation
AAPS PHARMSCITECH, v.14, no.1, pp.45 - 52
Abstract
In this study, liquid crystalline nanoparticles (LCN) have been proposed as new carrier for topical delivery of finasteride (FNS) in the treatment of androgenetic alopecia. To evaluate the potential of this nanocarrier, FNS-loaded LCN was prepared by ultrasonication method and characterized for size, shape, in vitro release, and skin permeation-retention properties. The particle size ranged from 153.8 to 170.2 nm with a cubical shape and exhibited controlled release profile with less than 20% of the drug released in the first 24 h. The release profile was significantly altered with addition of different additives. Formulation with lower monoolein exhibited higher skin permeation with a flux rate of 0.061 +/- 0.005 mu g cm(-2) h(-1) in 24 h. The permeation however, significantly increased with glycerol, propylene glycol, and polyethylene glycol 400, while it declined for the addition of oleic acid. A similar trend was observed with skin retention study. In conclusion, FNS-loaded LCN could be advocated as a viable alternative for oral administration of the drug.
URI
http://hdl.handle.net/YU.REPOSITORY/26288http://dx.doi.org/10.1208/s12249-012-9888-y
ISSN
1530-9932
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약학대학 > 약학부 > Articles
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