Serum amyloid A stimulates macrophage foam cell formation via lectin-like oxidized low-density lipoprotein receptor 1 upregulation

Title
Serum amyloid A stimulates macrophage foam cell formation via lectin-like oxidized low-density lipoprotein receptor 1 upregulation
Author(s)
조경현배외식[배외식]이하영[이하영]김상두[김상두]자벨[자벨]백석환최준혁
Keywords
CORONARY-ARTERY-DISEASE; ACUTE-PHASE PROTEIN; APOLIPOPROTEIN-A-I; NF-KAPPA-B; CCL2 PRODUCTION; SCAVENGER RECEPTORS; EXPRESSION; ATHEROSCLEROSIS; CHOLESTEROL; LOX-1
Issue Date
201303
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.433, no.1, pp.18 - 23
Abstract
Elevated levels of serum amyloid A (SAA) is a risk factor for cardiovascular diseases, however, the role of SAA in the pathophysiology of atherosclerosis remains unclear. Here we show that SAA induced macrophage foam cell formation. SAA-stimulated foam cell formation was mediated by c-jun N-terminal kinase (JNK) signaling. Moreover, both SAA and SAA-conjugated high density lipoprotein stimulated the expression of the important scavenger receptor lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) via nuclear factor-kappa B (NF-kappa B). A LOX1 antagonist carrageenan significantly blocked SAA-induced foam cell formation, indicating that SAA promotes foam cell formation via LOX1 expression. Our findings therefore suggest that SAA stimulates foam cell formation via LOX1 induction, and thus likely contributes to atherogenesis. (c) 2013 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/26255http://dx.doi.org/10.1016/j.bbrc.2013.02.077
ISSN
0006-291X
Appears in Collections:
생명공학부 > 생명공학부 > Articles
의과대학 > 생화학.분자생물학교실 > Articles
의과대학 > 병리학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE