Inclusion of hemoglobin level in prognostic score provides better prognostic stratification in patients with acute promyelocytic leukemia (APL)

Title
Inclusion of hemoglobin level in prognostic score provides better prognostic stratification in patients with acute promyelocytic leukemia (APL)
Author(s)
현명수박실비아[박실비아]이수진[이수진]김기현[김기현]장준호[장준호]김동환[김동환]이규형[이규형]이재환[이재환]장대영[장대영]김민경
Keywords
TRANS-RETINOIC ACID; RISK-ADAPTED TREATMENT; ANTHRACYCLINE MONOCHEMOTHERAPY; MOLECULAR PATHOGENESIS; REMISSION INDUCTION; PETHEMA GROUP; CONSOLIDATION; CYTARABINE; MANAGEMENT; THERAPY
Issue Date
201303
Publisher
SPRINGER JAPAN KK
Citation
INTERNATIONAL JOURNAL OF HEMATOLOGY, v.97, no.3, pp.388 - 396
Abstract
The clinical outcomes of acute promyelocytic leukemia (APL) have improved greatly, but treatment failure still occurs. Identification of patients with poor prognosis is fundamental, and we propose a new clinical prognostic system (CBC-score) consisting of WBC, platelet count, and hemoglobin level. Between 1995 and 2009, 156 patients with APL from seven institutes in Korea were retrospectively reviewed. In the new CBC-score system, each of the following (WBC a parts per thousand yen10 x 109/L, platelet < 40 x 109/L, hemoglobin < 8.0 g/dL) was considered as a risk factor; the sum of each was designated as the CBC-score. With a median follow-up of 8.4 years, the complete remission (CR) rate was 81.4 % (127/156), while 24 (15.4 %) were considered as treatment failures due to early death (ED). The 5-year overall survival (OS), leukemia-free survival, and cumulative incidence of relapse were 73.8, 82.8, and 13.5 %, respectively. Compared to the individual CBC parameters, combined prognostic systems such as PETHEMA or CBC-score provided better prognostic stratification. Compared to PETHEMA stratification, the proposed prognostic CBC-score system showed better stratification of APL patients in terms of CR rates (p = 0.004), OS (p = 0.004), and ED (p = 0.008). This retrospective study suggests that the proposed CBC-score may provide better prognostic stratification of APL patients.
URI
http://hdl.handle.net/YU.REPOSITORY/26225http://dx.doi.org/10.1007/s12185-013-1276-1
ISSN
0925-5710
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의과대학 > 내과학교실 > Articles
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