대장암에서 표적치료의 역할과 전망

Title
대장암에서 표적치료의 역할과 전망
Other Titles
A Perspective: Role of Targeted Therapy in Colon Cancer
Author(s)
장병익정현희[정현희]
Keywords
Colorectal neoplasms; Targeted molecular therapy
Issue Date
201303
Publisher
대한소화기학회
Citation
대한소화기학회지, v.61, no.3, pp.128 - 135
Abstract
Colorectal cancer is the third most common malignant disease in incidence according to a report in 2009 from Korea. The 5-fluorouracil (5-FU) remains to be a major chemotherapeutic agents. But, over the last 10-15 years, the treatment pattern for metastatic colorectal cancer changed significantly. Irinotecan and oxaliplatin are cytotoxic drugs, or bevacizumab and cetuximab are monoclonal antibodies against molecular targets. The introduction of novel agents targeting specific molecular features of cancer cells promises more options and marked improvements in efficacy for the treatment of metastatic colon cancer. Bevacizumab has been shown to extend survival in colorectal cancer when used in combination with irinotecan and 5-FU-based chemotherapy, and the addition of cetuximab to irinotecan and 5-FU-based chemotherapy eliminates irinotecan resistance. Better understanding of the tumor biology and the molecular pathway and mechanisms of tumorigenesis has led to the discovery of novel agents with improved outcomes.
URI
http://hdl.handle.net/YU.REPOSITORY/26120
ISSN
1598-9992
Appears in Collections:
의과대학 > 내과학교실 > Articles
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