Identification of novel single nucleotide polymorphisms (SNPs) of the lipoprotein lipase (LPL) gene associated with fatty acid composition in Korean cattle
- Identification of novel single nucleotide polymorphisms (SNPs) of the lipoprotein lipase (LPL) gene associated with fatty acid composition in Korean cattle
- 여정수; 오동엽; 라부미; 이윤석[이윤석]; 변윤화; 이제영; 여근혜[여근혜]
- ADIPOSE-TISSUE; STEERS; JAPANESE; LIPIDS; PALATABILITY; DOMAIN; BEEF; MEAT
- Issue Date
- MOLECULAR BIOLOGY REPORTS, v.40, no.4, pp.3155 - 3163
- The lipoprotein lipase (LPL) gene can be considered a functional candidate gene that regulates fatty acid composition. In this study, genetic associations between fatty acid composition and exonic single nucleotide polymorphisms (SNPs) in the LPL gene were examined using 612 Korean cattle. We investigated the relationship between unsaturated fatty acids and five novel SNPs (c.322G > A, c.329A > T, c.527T > G, c.988C > T and c.1591G > A), and confirmed that three polymorphic SNPs (c.322G > A, c.329A > T and c.1591G > A) were associated with fatty acid composition. Korean cattle with an AA genotype of c.322G > A, c.329A > T, and GA genotype of c.1591G > A had higher levels of monounsaturated fatty acids and carcass traits (P < 0.05). Our findings confirmed that three novel SNPs we identified in the LPL gene can affect fatty acid composition and carcass traits. Therefore, selection for AA and GA genotypes should be recommended to genetically improve beef quality and flavor.
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