Identification of novel single nucleotide polymorphisms (SNPs) of the lipoprotein lipase (LPL) gene associated with fatty acid composition in Korean cattle

Title
Identification of novel single nucleotide polymorphisms (SNPs) of the lipoprotein lipase (LPL) gene associated with fatty acid composition in Korean cattle
Author(s)
여정수오동엽라부미이윤석[이윤석]변윤화이제영여근혜[여근혜]
Keywords
ADIPOSE-TISSUE; STEERS; JAPANESE; LIPIDS; PALATABILITY; DOMAIN; BEEF; MEAT
Issue Date
201304
Publisher
SPRINGER
Citation
MOLECULAR BIOLOGY REPORTS, v.40, no.4, pp.3155 - 3163
Abstract
The lipoprotein lipase (LPL) gene can be considered a functional candidate gene that regulates fatty acid composition. In this study, genetic associations between fatty acid composition and exonic single nucleotide polymorphisms (SNPs) in the LPL gene were examined using 612 Korean cattle. We investigated the relationship between unsaturated fatty acids and five novel SNPs (c.322G > A, c.329A > T, c.527T > G, c.988C > T and c.1591G > A), and confirmed that three polymorphic SNPs (c.322G > A, c.329A > T and c.1591G > A) were associated with fatty acid composition. Korean cattle with an AA genotype of c.322G > A, c.329A > T, and GA genotype of c.1591G > A had higher levels of monounsaturated fatty acids and carcass traits (P < 0.05). Our findings confirmed that three novel SNPs we identified in the LPL gene can affect fatty acid composition and carcass traits. Therefore, selection for AA and GA genotypes should be recommended to genetically improve beef quality and flavor.
URI
http://hdl.handle.net/YU.REPOSITORY/26102http://dx.doi.org/10.1007/s11033-012-2389-y
ISSN
0301-4851
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생명공학부 > 생명공학부 > Articles
이과대학 > 통계학과 > Articles
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