Physicochemical characterization and in vivo evaluation of solid self-nanoemulsifying drug delivery system for oral administration of docetaxel

Title
Physicochemical characterization and in vivo evaluation of solid self-nanoemulsifying drug delivery system for oral administration of docetaxel
Author(s)
용철순Qizhe Quan[Qizhe Quan]김동욱[김동욱]마라시니니르말김대환김진기[김진기]최한곤[최한곤]김종오
Keywords
SPRAY-DRYING TECHNIQUE; MICROEMULSIFYING FORMULATION; BIOAVAILABILITY; RATS; EMULSIFICATION; ITRACONAZOLE; OPTIMIZATION; FLURBIPROFEN; SUPPOSITORY; TAXOTERE
Issue Date
201304
Publisher
INFORMA HEALTHCARE
Citation
JOURNAL OF MICROENCAPSULATION, v.30, no.4, pp.307 - 314
Abstract
To formulate a self-nanoemulsifying drug delivery system (SNEDDS) for the oral administration of docetaxel as an alternative to commercial docetaxel-loaded injectable products, it was prepared by spray-drying an aqueous solution containing liquid SNEDDS and colloidal silica. Its physicochemical properties and oral bioavailability were investigated compared to a clear docetaxel solution administered intravenously or orally to rats. In the docetaxel-loaded solid SNEDDS prepared with colloidal silica, the liquid SNEDDS composed of Capryol 90, Cremophore EL and Transcutol HP (45/35/20, volume ratio) was absorbed inside the pores of carriers, and docetaxel was present in a changed amorphous state. The solid SNEDDS with 3.3% (w/v) docetaxel produced nanoemulsions, and showed about 12.5% absolute bioavailability in rats. Thus, this solid SNEDDS may be a potential candidate for oral pharmaceutical product with improved oral bioavailability of docetaxel.
URI
http://hdl.handle.net/YU.REPOSITORY/26100http://dx.doi.org/10.3109/02652048.2012.726280
ISSN
0265-2048
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약학대학 > 약학부 > Articles
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